The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study
<p><strong>Background:</strong> The incidence of breast cancer first arising during pregnancy has been estimated in several countries to be 2.4–7.8/100,000 births, but has not been established in the United Kingdom (UK). We aimed to estimate the incidence of breast cancer diagnosed...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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F1000Research
2024
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| _version_ | 1824459053986742272 |
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| author | Hardy, C Brand, A Jones, J Knight, M Banfield, P |
| author_facet | Hardy, C Brand, A Jones, J Knight, M Banfield, P |
| author_sort | Hardy, C |
| collection | OXFORD |
| description | <p><strong>Background:</strong> The incidence of breast cancer first arising during pregnancy has been estimated in several countries to be 2.4–7.8/100,000 births, but has not been established in the United Kingdom (UK). We aimed to estimate the incidence of breast cancer diagnosed during pregnancy in the UK and to describe its management and short-term outcomes for mothers and babies.</p>
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<p><strong>Methods:</strong> This population-based descriptive study used the UK Obstetric Surveillance System (UKOSS). Cases were prospectively identified through monthly UKOSS mailings to all UK consultant-led maternity units. All cases of breast cancer diagnosed first during pregnancy, between October 1, 2015, and September 30, 2017, were eligible, with 84 confirmed cases analyzed. Women with breast cancer diagnosed before pregnancy or with a recurrence were excluded. The primary outcomes were the incidence of breast cancer first diagnosed during pregnancy, maternal mortality, severe maternal morbidity, perinatal mortality, and severe neonatal morbidity.</p>
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<p><strong>Results:</strong> The incidence was 5.4/100,000 maternities (95% CI 4.37, 6.70). Nine women (11%) had undergone in vitro fertilization (IVF), compared with an estimated 2.6% IVF pregnancies in the UK at that time. During pregnancy, 30 women (36%) underwent surgery and 37 women (44%) received chemotherapy. Three women had major maternal morbidity during pregnancy. Two women died and two perinatal deaths occurred.</p>
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<p><strong>Conclusions:</strong> The incidence of breast cancer arising in pregnancy in the UK is similar to that reported in other countries. The higher proportion of IVF pregnancies among women diagnosed with breast cancer during pregnancy needs further investigation, as it may not be entirely explained by relatively advanced maternal age. With caveats, the management followed that outside pregnancy, but there was considerable variation in practice. Although short-term outcomes were generally good for mothers and babies, a larger prospective study is required. It is often possible to avoid exposing the baby to iatrogenic prematurity.</p> |
| first_indexed | 2025-02-19T04:35:41Z |
| format | Journal article |
| id | oxford-uuid:ff28b932-d0a4-45ab-a60f-4d5b0cb9f825 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:35:41Z |
| publishDate | 2024 |
| publisher | F1000Research |
| record_format | dspace |
| spelling | oxford-uuid:ff28b932-d0a4-45ab-a60f-4d5b0cb9f8252025-01-23T12:20:07ZThe UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff28b932-d0a4-45ab-a60f-4d5b0cb9f825EnglishSymplectic ElementsF1000Research2024Hardy, CBrand, AJones, JKnight, MBanfield, P<p><strong>Background:</strong> The incidence of breast cancer first arising during pregnancy has been estimated in several countries to be 2.4–7.8/100,000 births, but has not been established in the United Kingdom (UK). We aimed to estimate the incidence of breast cancer diagnosed during pregnancy in the UK and to describe its management and short-term outcomes for mothers and babies.</p> <br> <p><strong>Methods:</strong> This population-based descriptive study used the UK Obstetric Surveillance System (UKOSS). Cases were prospectively identified through monthly UKOSS mailings to all UK consultant-led maternity units. All cases of breast cancer diagnosed first during pregnancy, between October 1, 2015, and September 30, 2017, were eligible, with 84 confirmed cases analyzed. Women with breast cancer diagnosed before pregnancy or with a recurrence were excluded. The primary outcomes were the incidence of breast cancer first diagnosed during pregnancy, maternal mortality, severe maternal morbidity, perinatal mortality, and severe neonatal morbidity.</p> <br> <p><strong>Results:</strong> The incidence was 5.4/100,000 maternities (95% CI 4.37, 6.70). Nine women (11%) had undergone in vitro fertilization (IVF), compared with an estimated 2.6% IVF pregnancies in the UK at that time. During pregnancy, 30 women (36%) underwent surgery and 37 women (44%) received chemotherapy. Three women had major maternal morbidity during pregnancy. Two women died and two perinatal deaths occurred.</p> <br> <p><strong>Conclusions:</strong> The incidence of breast cancer arising in pregnancy in the UK is similar to that reported in other countries. The higher proportion of IVF pregnancies among women diagnosed with breast cancer during pregnancy needs further investigation, as it may not be entirely explained by relatively advanced maternal age. With caveats, the management followed that outside pregnancy, but there was considerable variation in practice. Although short-term outcomes were generally good for mothers and babies, a larger prospective study is required. It is often possible to avoid exposing the baby to iatrogenic prematurity.</p> |
| spellingShingle | Hardy, C Brand, A Jones, J Knight, M Banfield, P The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title | The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title_full | The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title_fullStr | The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title_full_unstemmed | The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title_short | The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: a population-based descriptive study |
| title_sort | uk breast cancer in pregnancy ukbcip study incidence diagnosis management and short term outcomes of breast cancer first diagnosed during pregnancy in the united kingdom a population based descriptive study |
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