p53 coordinates base excision repair to prevent genomic instability

p53 coordinates base excision repair to prevent genomic instability

DNA constantly undergoes chemical modification due to endogenous and exogenous mutagens. The DNA base excision repair (BER) pathway is the frontline mechanism handling the majority of these lesions, and primarily involves a DNA incision and subsequent resealing step. It is imperative that these proc...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Poletto, M, Legrand, A, Fletcher, S, Dianov, G
Fformat:	Journal article
Cyhoeddwyd:	Oxford University Press 2016

Eitemau Tebyg

DNA base excision repair: the Achilles' heel of tumour cells and their microenvironment?
gan: Poletto, M, et al.
Cyhoeddwyd: (2017)

Regulation of the base excision repair pathway
gan: Fletcher, S, et al.
Cyhoeddwyd: (2017)

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
gan: Poletto, M, et al.
Cyhoeddwyd: (2017)

Co-ordination of base excision repair and genome stability.
gan: Parsons, J, et al.
Cyhoeddwyd: (2013)

Base excision repair targets for cancer therapy.
gan: Dianov, G
Cyhoeddwyd: (2011)

Monitoring base excision repair by in vitro assays.
gan: Dianov, G
Cyhoeddwyd: (2003)

Mammalian base excision repair: the forgotten archangel.
gan: Dianov, G, et al.
Cyhoeddwyd: (2013)

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
gan: Chen, X, et al.
Cyhoeddwyd: (2018)

Targeting base excision repair to improve cancer therapies.
gan: Sharma, R, et al.
Cyhoeddwyd: (2007)

DNA repair fidelity of base excision repair pathways in human cell extracts.
gan: Zhang, Q, et al.
Cyhoeddwyd: (2005)

The emerging role of Mule and ARF in the regulation of base excision repair.
gan: Khoronenkova, S, et al.
Cyhoeddwyd: (2011)

The emerging role of Mule and ARF in the regulation of base excision repair
gan: Khoronenkova, S, et al.
Cyhoeddwyd: (2011)

Base excision repair fidelity in normal and cancer cells.
gan: Chan, K, et al.
Cyhoeddwyd: (2006)

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability
gan: Markkanen, E, et al.
Cyhoeddwyd: (2015)

In vitro base excision repair using mammalian cell extracts.
gan: Parsons, J, et al.
Cyhoeddwyd: (2012)

Orchestration of base excision repair by controlling the rates of enzymatic activities.
gan: Allinson, S, et al.
Cyhoeddwyd: (2004)

Exchangeability of mammalian DNA ligases between base excision repair pathways.
gan: Sleeth, K, et al.
Cyhoeddwyd: (2004)

Monitoring base excision repair proteins on damaged DNA using human cell extracts.
gan: Parsons, J, et al.
Cyhoeddwyd: (2004)

Isolation of a small molecule inhibitor of DNA base excision repair.
gan: Madhusudan, S, et al.
Cyhoeddwyd: (2005)

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
gan: Dianova, I, et al.
Cyhoeddwyd: (2004)

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
gan: Parsons, J, et al.
Cyhoeddwyd: (2009)

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
gan: Parsons, J, et al.
Cyhoeddwyd: (2008)

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
gan: Chan, K, et al.
Cyhoeddwyd: (2007)

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
gan: Parsons, J, et al.
Cyhoeddwyd: (2005)

P53 maintains genomic stability by preventing interference between transcription and replication
gan: Yeo, Constance Qiao Xin, et al.
Cyhoeddwyd: (2018)

DNA repair and genomic instability in yeast aging
gan: Park, Peter Unnam, 1971-
Cyhoeddwyd: (2005)

Mechanistic studies of DNA repair and genome instability
gan: Nathan, WJ
Cyhoeddwyd: (2021)

Functional DNA repair capacity assays : a focus on base excision repair
gan: Chaim, Isaac Alexander
Cyhoeddwyd: (2016)

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
gan: Yang, J, et al.
Cyhoeddwyd: (2010)

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
gan: Parsons, J, et al.
Cyhoeddwyd: (2011)

p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
gan: Boyd, Scott D. (Scott Dexter), 1970-
Cyhoeddwyd: (2006)

Nitric oxide induced S-nitrosation causes base excision repair imbalance
gan: Engelward, Bevin P., et al.
Cyhoeddwyd: (2020)

XRCC1 and base excision repair balance in response to nitric oxide
gan: Svilar, David, et al.
Cyhoeddwyd: (2017)

The structural basis of specific base-excision repair by uracil-DNA glycosylase.
gan: Savva, R, et al.
Cyhoeddwyd: (1995)

Base excision repair of radiation-induced DNA damage in mammalian cells
gan: Cooper, S, et al.
Cyhoeddwyd: (2013)

Supercoiling of an excised genomic island represses effector gene expression to prevent activation of host resistance
gan: Neale, H, et al.
Cyhoeddwyd: (2018)

p53 prevents entry into mitosis with uncapped telomeres.
gan: Thanasoula, M, et al.
Cyhoeddwyd: (2010)

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.
gan: Ström, C, et al.
Cyhoeddwyd: (2011)

Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast
gan: Admiraal, SJ, et al.
Cyhoeddwyd: (2019)

The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin
gan: Kartalou, Maria, 1972-
Cyhoeddwyd: (Cisp)