Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice
Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal in...
| المؤلفون الرئيسيون: | , , , |
|---|---|
| التنسيق: | Journal article |
| منشور في: |
Frontiers Media
2019
|
| _version_ | 1826307235537485824 |
|---|---|
| author | Francavilla, R Villette, V Martel, O Topolnik, L |
| author_facet | Francavilla, R Villette, V Martel, O Topolnik, L |
| author_sort | Francavilla, R |
| collection | OXFORD |
| description | Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake behaving animals. However, little is still known about dendritic Ca2+ activity in interneurons during different behavioral states. Here, we used two-photon Ca2+ imaging in mouse hippocampal CA1 interneurons to reveal Ca2+ signal patterns in interneuron dendrites during animal locomotion and immobility. Despite overall variability in dendritic Ca2+ transients (CaTs) across different cells and dendritic branches, we report consistent behavior state-dependent organization of Ca2+ signaling in interneurons. As such, spreading regenerative CaTs dominated in dendrites during locomotion, whereas both spreading and localized Ca2+ signals were seen during immobility. Thus, these data indicate that while animal locomotion is associated with widespread Ca2+ elevations in interneuron dendrites that may reflect regenerative activity, local CaTs that may be related to synaptic activity become apparent during animal quiet state. |
| first_indexed | 2024-03-07T06:59:52Z |
| format | Journal article |
| id | oxford-uuid:ff5e6266-25d6-41cb-b587-a90018c5ddc4 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:59:52Z |
| publishDate | 2019 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:ff5e6266-25d6-41cb-b587-a90018c5ddc42022-03-27T13:44:27ZCalcium dynamics in dendrites of hippocampal CA1 interneurons in awake miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff5e6266-25d6-41cb-b587-a90018c5ddc4Symplectic Elements at OxfordFrontiers Media2019Francavilla, RVillette, VMartel, OTopolnik, LHippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake behaving animals. However, little is still known about dendritic Ca2+ activity in interneurons during different behavioral states. Here, we used two-photon Ca2+ imaging in mouse hippocampal CA1 interneurons to reveal Ca2+ signal patterns in interneuron dendrites during animal locomotion and immobility. Despite overall variability in dendritic Ca2+ transients (CaTs) across different cells and dendritic branches, we report consistent behavior state-dependent organization of Ca2+ signaling in interneurons. As such, spreading regenerative CaTs dominated in dendrites during locomotion, whereas both spreading and localized Ca2+ signals were seen during immobility. Thus, these data indicate that while animal locomotion is associated with widespread Ca2+ elevations in interneuron dendrites that may reflect regenerative activity, local CaTs that may be related to synaptic activity become apparent during animal quiet state. |
| spellingShingle | Francavilla, R Villette, V Martel, O Topolnik, L Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title | Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title_full | Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title_fullStr | Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title_full_unstemmed | Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title_short | Calcium dynamics in dendrites of hippocampal CA1 interneurons in awake mice |
| title_sort | calcium dynamics in dendrites of hippocampal ca1 interneurons in awake mice |
| work_keys_str_mv | AT francavillar calciumdynamicsindendritesofhippocampalca1interneuronsinawakemice AT villettev calciumdynamicsindendritesofhippocampalca1interneuronsinawakemice AT martelo calciumdynamicsindendritesofhippocampalca1interneuronsinawakemice AT topolnikl calciumdynamicsindendritesofhippocampalca1interneuronsinawakemice |