Synthesis of the taxol core via catalytic asymmetric 1,4-addition of an Alkylzirconium Nucleophile
The Taxol core was prepared in five steps via a key copper-catalyzed asymmetric conjugate addition trapping sequence. The use of a bromodiene-derived alkylzirconium nucleophile followed by trapping with POCl3/DMF gave a highly functionalized intermediate featuring a quaternary center in 69% yield wi...
Autori principali: | Wang, JYJ, Fletcher, S |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
American Chemical Society
2020
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