Synthesis of the taxol core via catalytic asymmetric 1,4-addition of an Alkylzirconium Nucleophile
The Taxol core was prepared in five steps via a key copper-catalyzed asymmetric conjugate addition trapping sequence. The use of a bromodiene-derived alkylzirconium nucleophile followed by trapping with POCl3/DMF gave a highly functionalized intermediate featuring a quaternary center in 69% yield wi...
Asıl Yazarlar: | , |
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Materyal Türü: | Journal article |
Dil: | English |
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American Chemical Society
2020
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