Common variants at 12q15 and 12q24 are associated with infant head circumference
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication stud...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797106359039164416 |
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| author | Rob Taal, H St Pourcain, B Thiering, E Das, S Mook-Kanamori, DO Warrington, N Kaakinen, M Kreiner-Møller, E Bradfield, J Freathy, R Geller, F Guxens, M Cousminer, D Kerkhof, M Timpson, N Ikram, M Beilin, L Bønnelykke, K Buxton, J Charoen, P Chawes, B Eriksson, J Evans, D Hofman, A Kemp, J |
| author_facet | Rob Taal, H St Pourcain, B Thiering, E Das, S Mook-Kanamori, DO Warrington, N Kaakinen, M Kreiner-Møller, E Bradfield, J Freathy, R Geller, F Guxens, M Cousminer, D Kerkhof, M Timpson, N Ikram, M Beilin, L Bønnelykke, K Buxton, J Charoen, P Chawes, B Eriksson, J Evans, D Hofman, A Kemp, J |
| author_sort | Rob Taal, H |
| collection | OXFORD |
| description | To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. © 2012 Nature America, Inc. All rights reserved. |
| first_indexed | 2024-03-07T07:00:28Z |
| format | Journal article |
| id | oxford-uuid:ff934ce9-6c61-46bb-b404-1d2919fb1595 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:00:28Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:ff934ce9-6c61-46bb-b404-1d2919fb15952022-03-27T13:46:01ZCommon variants at 12q15 and 12q24 are associated with infant head circumferenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff934ce9-6c61-46bb-b404-1d2919fb1595EnglishSymplectic Elements at Oxford2012Rob Taal, HSt Pourcain, BThiering, EDas, SMook-Kanamori, DOWarrington, NKaakinen, MKreiner-Møller, EBradfield, JFreathy, RGeller, FGuxens, MCousminer, DKerkhof, MTimpson, NIkram, MBeilin, LBønnelykke, KBuxton, JCharoen, PChawes, BEriksson, JEvans, DHofman, AKemp, JTo identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. © 2012 Nature America, Inc. All rights reserved. |
| spellingShingle | Rob Taal, H St Pourcain, B Thiering, E Das, S Mook-Kanamori, DO Warrington, N Kaakinen, M Kreiner-Møller, E Bradfield, J Freathy, R Geller, F Guxens, M Cousminer, D Kerkhof, M Timpson, N Ikram, M Beilin, L Bønnelykke, K Buxton, J Charoen, P Chawes, B Eriksson, J Evans, D Hofman, A Kemp, J Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title | Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title_full | Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title_fullStr | Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title_full_unstemmed | Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title_short | Common variants at 12q15 and 12q24 are associated with infant head circumference |
| title_sort | common variants at 12q15 and 12q24 are associated with infant head circumference |
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