Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.
Weight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region...
| Những tác giả chính: | , , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2009
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| _version_ | 1826307279356428288 |
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| author | Godlewska, B Olajossy-Hilkesberger, L Ciwoniuk, M Olajossy, M Marmurowska-Michałowska, H Limon, J Landowski, J |
| author_facet | Godlewska, B Olajossy-Hilkesberger, L Ciwoniuk, M Olajossy, M Marmurowska-Michałowska, H Limon, J Landowski, J |
| author_sort | Godlewska, B |
| collection | OXFORD |
| description | Weight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region of this gene: -759C/T (rs3813929) and -697G/C (rs518147), with weight gain after 6 weeks of olanzapine monotherapy. It included 107 patients with schizophrenia; among them 36 are first-episode drug-naive patients. Analysis was carried out by PCR-restriction fragment length polymorphism. A protective effect of -759T and -697C alleles was found: significantly less patients with -697C (3/51) and no patient with -759T (0/28) alleles experienced body mass index increase >or=10% (P=0.0006 and 0.002, respectively). The same was true for drug-naive patients possessing any of the variant alleles. There was a significant association of haplotypes with a >or=10% body mass index increase (P=0.001). On the basis of the additional statistical analysis, the more important role of -697C allele was suggested. |
| first_indexed | 2024-03-07T07:00:32Z |
| format | Journal article |
| id | oxford-uuid:ff969add-5782-4cd6-ab54-1f3535c7e663 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:00:32Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:ff969add-5782-4cd6-ab54-1f3535c7e6632022-03-27T13:46:07ZOlanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff969add-5782-4cd6-ab54-1f3535c7e663EnglishSymplectic Elements at Oxford2009Godlewska, BOlajossy-Hilkesberger, LCiwoniuk, MOlajossy, MMarmurowska-Michałowska, HLimon, JLandowski, JWeight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region of this gene: -759C/T (rs3813929) and -697G/C (rs518147), with weight gain after 6 weeks of olanzapine monotherapy. It included 107 patients with schizophrenia; among them 36 are first-episode drug-naive patients. Analysis was carried out by PCR-restriction fragment length polymorphism. A protective effect of -759T and -697C alleles was found: significantly less patients with -697C (3/51) and no patient with -759T (0/28) alleles experienced body mass index increase >or=10% (P=0.0006 and 0.002, respectively). The same was true for drug-naive patients possessing any of the variant alleles. There was a significant association of haplotypes with a >or=10% body mass index increase (P=0.001). On the basis of the additional statistical analysis, the more important role of -697C allele was suggested. |
| spellingShingle | Godlewska, B Olajossy-Hilkesberger, L Ciwoniuk, M Olajossy, M Marmurowska-Michałowska, H Limon, J Landowski, J Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title | Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title_full | Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title_fullStr | Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title_full_unstemmed | Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title_short | Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. |
| title_sort | olanzapine induced weight gain is associated with the 759c t and 697g c polymorphisms of the htr2c gene |
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