The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat.
The 5-HT1A agonist 8-OH-DPAT, at a dose of 30 micrograms/kg, enhanced the consumption of sweetened wet mash and sweetened milk in non-deprived rats. In partially satiated rats, sensitivity to the hyperphagic effect of 8-OH-DPAT on wet mash intake was substantially increased, so that the minimally ef...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1988
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| _version_ | 1826307286042148864 |
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| author | Dourish, C Cooper, S Gilbert, F Coughlan, J Iversen, S |
| author_facet | Dourish, C Cooper, S Gilbert, F Coughlan, J Iversen, S |
| author_sort | Dourish, C |
| collection | OXFORD |
| description | The 5-HT1A agonist 8-OH-DPAT, at a dose of 30 micrograms/kg, enhanced the consumption of sweetened wet mash and sweetened milk in non-deprived rats. In partially satiated rats, sensitivity to the hyperphagic effect of 8-OH-DPAT on wet mash intake was substantially increased, so that the minimally effective dose was reduced to 3 micrograms/kg. Similarly, 8-OH-DPAT was more efficacious in increasing milk intake in satiated rats. Thus, 30 and 40 micrograms/kg 8-OH-DPAT produced a 4-fold increase of milk intake in completely satiated rats compared to a 2-fold increase in partially satiated animals at a dose of 30 micrograms/kg. The increased intake of liquid and wet mash diets observed after treatment with low doses of 8-OH-DPAT argues against the involvement of non-specific gnawing in the increased consumption of solid food produced by the drug. Rather, the data suggest that 8-OH-DPAT may specifically stimulate appetite by counteracting a tonic serotonergic inhibition of feeding. The present experiments also showed that 8-OH-DPAT attenuates fenfluramine-induced anorexia which is thought to depend on increased serotonergic neurotransmission. |
| first_indexed | 2024-03-07T07:00:38Z |
| format | Journal article |
| id | oxford-uuid:ffa09b50-5e6c-4b01-a692-671aeff422b5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:00:38Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:ffa09b50-5e6c-4b01-a692-671aeff422b52022-03-27T13:46:19ZThe 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ffa09b50-5e6c-4b01-a692-671aeff422b5EnglishSymplectic Elements at Oxford1988Dourish, CCooper, SGilbert, FCoughlan, JIversen, SThe 5-HT1A agonist 8-OH-DPAT, at a dose of 30 micrograms/kg, enhanced the consumption of sweetened wet mash and sweetened milk in non-deprived rats. In partially satiated rats, sensitivity to the hyperphagic effect of 8-OH-DPAT on wet mash intake was substantially increased, so that the minimally effective dose was reduced to 3 micrograms/kg. Similarly, 8-OH-DPAT was more efficacious in increasing milk intake in satiated rats. Thus, 30 and 40 micrograms/kg 8-OH-DPAT produced a 4-fold increase of milk intake in completely satiated rats compared to a 2-fold increase in partially satiated animals at a dose of 30 micrograms/kg. The increased intake of liquid and wet mash diets observed after treatment with low doses of 8-OH-DPAT argues against the involvement of non-specific gnawing in the increased consumption of solid food produced by the drug. Rather, the data suggest that 8-OH-DPAT may specifically stimulate appetite by counteracting a tonic serotonergic inhibition of feeding. The present experiments also showed that 8-OH-DPAT attenuates fenfluramine-induced anorexia which is thought to depend on increased serotonergic neurotransmission. |
| spellingShingle | Dourish, C Cooper, S Gilbert, F Coughlan, J Iversen, S The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title | The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title_full | The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title_fullStr | The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title_full_unstemmed | The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title_short | The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. |
| title_sort | 5 ht1a agonist 8 oh dpat increases consumption of palatable wet mash and liquid diets in the rat |
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