Commentary: T cells get by with a little help from their friends.
In animal models, lymphocytic choriomeningitis virus (LCMV) may be controlled after acute infection or may establish various levels of persistence. Cytotoxic responses mediated by CD8(+) T cells are responsible for both initial control of LCMV and for immunopathology. As discussed in this article, t...
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797106395354497024 |
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| author | Klenerman, P |
| author_facet | Klenerman, P |
| author_sort | Klenerman, P |
| collection | OXFORD |
| description | In animal models, lymphocytic choriomeningitis virus (LCMV) may be controlled after acute infection or may establish various levels of persistence. Cytotoxic responses mediated by CD8(+) T cells are responsible for both initial control of LCMV and for immunopathology. As discussed in this article, there is emerging evidence that the levels of antigen to which the immune system is exposed over time are important in controlling CD8(+) T cell activation, memory responses and exhaustion, and that these levels are affected by the efficiency of T cell help and the presence of antibody. To enable lasting control of LCMV infection, CD8(+) T cells, CD4(+) T cell help and B cells are all required. These findings have important implications for the prevention and treatment of infection by viruses such as hepatitis B and C viruses, cytomegalovirus and HIV. See accompanying article http://dx.doi.org/10.1002/eji.200324717 |
| first_indexed | 2024-03-07T07:01:01Z |
| format | Journal article |
| id | oxford-uuid:ffbee6aa-d573-49b2-adf0-a8186b8f2042 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:01:01Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:ffbee6aa-d573-49b2-adf0-a8186b8f20422022-03-27T13:47:29ZCommentary: T cells get by with a little help from their friends.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ffbee6aa-d573-49b2-adf0-a8186b8f2042EnglishSymplectic Elements at Oxford2004Klenerman, PIn animal models, lymphocytic choriomeningitis virus (LCMV) may be controlled after acute infection or may establish various levels of persistence. Cytotoxic responses mediated by CD8(+) T cells are responsible for both initial control of LCMV and for immunopathology. As discussed in this article, there is emerging evidence that the levels of antigen to which the immune system is exposed over time are important in controlling CD8(+) T cell activation, memory responses and exhaustion, and that these levels are affected by the efficiency of T cell help and the presence of antibody. To enable lasting control of LCMV infection, CD8(+) T cells, CD4(+) T cell help and B cells are all required. These findings have important implications for the prevention and treatment of infection by viruses such as hepatitis B and C viruses, cytomegalovirus and HIV. See accompanying article http://dx.doi.org/10.1002/eji.200324717 |
| spellingShingle | Klenerman, P Commentary: T cells get by with a little help from their friends. |
| title | Commentary: T cells get by with a little help from their friends. |
| title_full | Commentary: T cells get by with a little help from their friends. |
| title_fullStr | Commentary: T cells get by with a little help from their friends. |
| title_full_unstemmed | Commentary: T cells get by with a little help from their friends. |
| title_short | Commentary: T cells get by with a little help from their friends. |
| title_sort | commentary t cells get by with a little help from their friends |
| work_keys_str_mv | AT klenermanp commentarytcellsgetbywithalittlehelpfromtheirfriends |