Phase I dose escalation study of Linsitinib (OSI-906) and Erlotinib in patients with advanced solid tumors

Phase I dose escalation study of Linsitinib (OSI-906) and Erlotinib in patients with advanced solid tumors

Cross-talk between type 1 IGF receptor (IGF-1R), insulin receptor (INSR) and epidermal growth factor receptor (EGFR) mediates resistance to individual receptor blockade. This study aimed to determine the MTD, safety, pharmacokinetics, pharmacodynamics and preliminary antitumor activity of linsitinib...

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Bibliographic Details
Main Authors:	Macaulay, V, Middleton, M, Eckhardt, S, Rudin, C, Juergens, R, Gedrich, R, Gogov, S, McCarthy, S, Poondru, S, Stephens, A, Gadgeel, S
Format:	Journal article
Language:	English
Published:	American Association for Cancer Research 2016

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