Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study
Diffusion tensor imaging (DTI) offers parameter indices, namely, mean diffusivity (MD) and fractional anisotropy (FA). Leukoaraiosis is a brain white matter hyperintensity as observed on fluid-attenuated inversion recovery (FLAIR) images. In this study, we attempt to assess leukoaraiosis at its spec...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15350/1/8.pdf |
| _version_ | 1796932235180376064 |
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| author | Nur Hartini Mohd Taib, Wan Ahmad Kamil Wan Abdullah, Ibrahim Lutfi Shuaib, Muhammad Nur Salihin Yusoff, Enrico Magosso, Suzana Mat Isa, Ahmad Hadif Zaidin Samsudin, |
| author_facet | Nur Hartini Mohd Taib, Wan Ahmad Kamil Wan Abdullah, Ibrahim Lutfi Shuaib, Muhammad Nur Salihin Yusoff, Enrico Magosso, Suzana Mat Isa, Ahmad Hadif Zaidin Samsudin, |
| author_sort | Nur Hartini Mohd Taib, |
| collection | UKM |
| description | Diffusion tensor imaging (DTI) offers parameter indices, namely, mean diffusivity (MD) and fractional anisotropy (FA). Leukoaraiosis is a brain white matter hyperintensity as observed on fluid-attenuated inversion recovery (FLAIR) images. In this study, we attempt to assess leukoaraiosis at its specific spot using a new parameter, namely, lesion-to-normal appearing white matter ratio (LNR). LNR was then used to investigate the relationship between the volume of leukoaraiosis spot and the degree of tissue damage. This study involved 49 leukoaraiosis subjects who altogether contributed to 274 leukoaraiosis spots. The MD, FA, and volume were measured at each spot. LNR was calculated by comparing the MD values of the spot with those of the surrounding normal-appearing white matter (NAWM). The correlation between MD, FA, and LNR with leukoaraiosis volume was then analysed. The leukoaraiosis tissues generally exhibited higher MD (103.97 ± 12.32 × 10-5 mm2/s) and lower FA (0.31 ± 0.08) values than the NAWM tissues (79.30 ± 4.76 × 10-5 mm2/s and 0.41 ± 0.09, respectively). LNR values were found to range from 0.04 to 1.63. The results showed an insignificant association between the leukoaraiosis volume and LNR [r = −.055, p = .368], whereas a very weak association was shown with MD [r = −.196,p =.001] and FA [r = .268, p < .001]. The volume of the leukoaraiosis spot does not necessarily indicate the degree of tissue damage. By using LNR instead of MD, an accurate analysis was performed since the variability of MD for NAWM surrounding the lesion is taken into account. |
| first_indexed | 2024-03-06T04:29:52Z |
| format | Article |
| id | ukm.eprints-15350 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:29:52Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-153502020-10-16T00:32:03Z http://journalarticle.ukm.my/15350/ Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study Nur Hartini Mohd Taib, Wan Ahmad Kamil Wan Abdullah, Ibrahim Lutfi Shuaib, Muhammad Nur Salihin Yusoff, Enrico Magosso, Suzana Mat Isa, Ahmad Hadif Zaidin Samsudin, Diffusion tensor imaging (DTI) offers parameter indices, namely, mean diffusivity (MD) and fractional anisotropy (FA). Leukoaraiosis is a brain white matter hyperintensity as observed on fluid-attenuated inversion recovery (FLAIR) images. In this study, we attempt to assess leukoaraiosis at its specific spot using a new parameter, namely, lesion-to-normal appearing white matter ratio (LNR). LNR was then used to investigate the relationship between the volume of leukoaraiosis spot and the degree of tissue damage. This study involved 49 leukoaraiosis subjects who altogether contributed to 274 leukoaraiosis spots. The MD, FA, and volume were measured at each spot. LNR was calculated by comparing the MD values of the spot with those of the surrounding normal-appearing white matter (NAWM). The correlation between MD, FA, and LNR with leukoaraiosis volume was then analysed. The leukoaraiosis tissues generally exhibited higher MD (103.97 ± 12.32 × 10-5 mm2/s) and lower FA (0.31 ± 0.08) values than the NAWM tissues (79.30 ± 4.76 × 10-5 mm2/s and 0.41 ± 0.09, respectively). LNR values were found to range from 0.04 to 1.63. The results showed an insignificant association between the leukoaraiosis volume and LNR [r = −.055, p = .368], whereas a very weak association was shown with MD [r = −.196,p =.001] and FA [r = .268, p < .001]. The volume of the leukoaraiosis spot does not necessarily indicate the degree of tissue damage. By using LNR instead of MD, an accurate analysis was performed since the variability of MD for NAWM surrounding the lesion is taken into account. Penerbit Universiti Kebangsaan Malaysia 2020-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15350/1/8.pdf Nur Hartini Mohd Taib, and Wan Ahmad Kamil Wan Abdullah, and Ibrahim Lutfi Shuaib, and Muhammad Nur Salihin Yusoff, and Enrico Magosso, and Suzana Mat Isa, and Ahmad Hadif Zaidin Samsudin, (2020) Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study. Sains Malaysiana, 49 (4). pp. 793-800. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil4_2020/KandunganJilid49Bil4_2020.html |
| spellingShingle | Nur Hartini Mohd Taib, Wan Ahmad Kamil Wan Abdullah, Ibrahim Lutfi Shuaib, Muhammad Nur Salihin Yusoff, Enrico Magosso, Suzana Mat Isa, Ahmad Hadif Zaidin Samsudin, Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title | Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title_full | Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title_fullStr | Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title_full_unstemmed | Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title_short | Relationship between volume of leukoaraiosis spot and degree of tissue damage: a quantitative diffusion tensor imaging study |
| title_sort | relationship between volume of leukoaraiosis spot and degree of tissue damage a quantitative diffusion tensor imaging study |
| url | http://journalarticle.ukm.my/15350/1/8.pdf |
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