Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur

Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye (DE) patients. This study evaluated the MGDo and its association with lid margin...

Full description

Bibliographic Details
Main Authors: Mohamad Hanif Hajar Maidin, Bariah Mohd-Ali, Zainora Mohammed, Jamaludin Mohamed
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/15351/1/9.pdf
_version_ 1796932235374362624
author Mohamad Hanif Hajar Maidin,
Bariah Mohd-Ali,
Zainora Mohammed,
Jamaludin Mohamed,
author_facet Mohamad Hanif Hajar Maidin,
Bariah Mohd-Ali,
Zainora Mohammed,
Jamaludin Mohamed,
author_sort Mohamad Hanif Hajar Maidin,
collection UKM
description Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye (DE) patients. This study evaluated the MGDo and its association with lid margin inflammation in young adults using meibography and lid wiper epitheliopathy (LWE) techniques. Other ocular surface appearance (cornea, conjunctiva and limbus) were also examined. A total of 107 healthy noncontact lens wearers were evaluated (mean age: 23.06 ± 2.63 years old). All subjects were screened with McMonnies Dry Eye Questionnaire (MDEQ) before undergoing clinical investigations using slit-lamp biomicroscope, LWE and meibography. Cornea, conjunctiva and limbus appearances were graded using the Efron grading scale. Following the MDEQ score, 36 subjects were classified as DE (mean 16.49 ± 1.74), and 71 subjects were classified as non-DE (NDE, mean score: 7.23 ± 3.09). The difference in corneal staining between both groups was significant (χ2 [1, N = 107] = 18.01, p < 0.05). A total of 70% of subjects had LWE staining which was more apparent in subjects with DE (χ2 [1, N = 107] = 13.17, p < 0.01). The meiboscore indicated that 44.85% of subjects had MGDo, with a higher percentage (72.22%) in DE. There were significant differences between meiboscore in both groups (χ2 [1, N = 107] = 16.42, p < 0.05). However, there was weak and insignificant correlation between LWE and meiboscore (rs = 0.14, p = 0.16). Positive correlations were noted between MDEQ and LWE (rs = 0.49, p < 0.01), MDEQ and corneal staining (rs = 0.36, p < 0.01) and MDEQ and meiboscore (rs = 0.24, p < 0.05). The results of this study demonstrated the differences in MGDo, LWE and ocular surface appearances between DE and NDE of the young adults but MGDo was not associated with LWE. Larger number of subjects is needed to confirm these findings.
first_indexed 2024-03-06T04:29:52Z
format Article
id ukm.eprints-15351
institution Universiti Kebangsaan Malaysia
language English
last_indexed 2024-03-06T04:29:52Z
publishDate 2020
publisher Penerbit Universiti Kebangsaan Malaysia
record_format dspace
spelling ukm.eprints-153512020-10-16T00:33:07Z http://journalarticle.ukm.my/15351/ Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur Mohamad Hanif Hajar Maidin, Bariah Mohd-Ali, Zainora Mohammed, Jamaludin Mohamed, Meibomian gland dropout (MGDo) refers to partial or total loss of the acinar tissues which can be detected by meibography. It is possible that MGDo can be associated with lid margin inflammation commonly seen in dry eye (DE) patients. This study evaluated the MGDo and its association with lid margin inflammation in young adults using meibography and lid wiper epitheliopathy (LWE) techniques. Other ocular surface appearance (cornea, conjunctiva and limbus) were also examined. A total of 107 healthy noncontact lens wearers were evaluated (mean age: 23.06 ± 2.63 years old). All subjects were screened with McMonnies Dry Eye Questionnaire (MDEQ) before undergoing clinical investigations using slit-lamp biomicroscope, LWE and meibography. Cornea, conjunctiva and limbus appearances were graded using the Efron grading scale. Following the MDEQ score, 36 subjects were classified as DE (mean 16.49 ± 1.74), and 71 subjects were classified as non-DE (NDE, mean score: 7.23 ± 3.09). The difference in corneal staining between both groups was significant (χ2 [1, N = 107] = 18.01, p < 0.05). A total of 70% of subjects had LWE staining which was more apparent in subjects with DE (χ2 [1, N = 107] = 13.17, p < 0.01). The meiboscore indicated that 44.85% of subjects had MGDo, with a higher percentage (72.22%) in DE. There were significant differences between meiboscore in both groups (χ2 [1, N = 107] = 16.42, p < 0.05). However, there was weak and insignificant correlation between LWE and meiboscore (rs = 0.14, p = 0.16). Positive correlations were noted between MDEQ and LWE (rs = 0.49, p < 0.01), MDEQ and corneal staining (rs = 0.36, p < 0.01) and MDEQ and meiboscore (rs = 0.24, p < 0.05). The results of this study demonstrated the differences in MGDo, LWE and ocular surface appearances between DE and NDE of the young adults but MGDo was not associated with LWE. Larger number of subjects is needed to confirm these findings. Penerbit Universiti Kebangsaan Malaysia 2020-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15351/1/9.pdf Mohamad Hanif Hajar Maidin, and Bariah Mohd-Ali, and Zainora Mohammed, and Jamaludin Mohamed, (2020) Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur. Sains Malaysiana, 49 (4). pp. 801-808. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil4_2020/KandunganJilid49Bil4_2020.html
spellingShingle Mohamad Hanif Hajar Maidin,
Bariah Mohd-Ali,
Zainora Mohammed,
Jamaludin Mohamed,
Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_full Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_fullStr Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_full_unstemmed Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_short Meibomian gland dropout and ocular surface appearances of young adults in Kuala Lumpur
title_sort meibomian gland dropout and ocular surface appearances of young adults in kuala lumpur
url http://journalarticle.ukm.my/15351/1/9.pdf
work_keys_str_mv AT mohamadhanifhajarmaidin meibomianglanddropoutandocularsurfaceappearancesofyoungadultsinkualalumpur
AT bariahmohdali meibomianglanddropoutandocularsurfaceappearancesofyoungadultsinkualalumpur
AT zainoramohammed meibomianglanddropoutandocularsurfaceappearancesofyoungadultsinkualalumpur
AT jamaludinmohamed meibomianglanddropoutandocularsurfaceappearancesofyoungadultsinkualalumpur