3D titanium scaffold properties and osteogenesis of stem cells
Studies on porous titanium for use in dental applications have been growing due to their excellent properties such as low elastic modulus, biocompatibility and excellent strength. The porosity and pore size of titanium scaffold play an important role in bone formation. Thus, this paper reviews the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15352/1/10.pdf |
| _version_ | 1796932235571494912 |
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| author | Rohaya Megat Abdul Wahab, Manal Nabil Hagar, Nur Atmaliya Luchman, Farinawati Yazid, Shahrul Hisham Zainal Ariffin, |
| author_facet | Rohaya Megat Abdul Wahab, Manal Nabil Hagar, Nur Atmaliya Luchman, Farinawati Yazid, Shahrul Hisham Zainal Ariffin, |
| author_sort | Rohaya Megat Abdul Wahab, |
| collection | UKM |
| description | Studies on porous titanium for use in dental applications have been growing due to their excellent properties such as low
elastic modulus, biocompatibility and excellent strength. The porosity and pore size of titanium scaffold play an important
role in bone formation. Thus, this paper reviews the properties of titanium scaffold and the relationship between the
porosity and pore size of titanium with the osteogenesis of stem cells in respect of its mechanical properties and biological
assessment. From this review, it was found that a pore size of less than 300 μm allows for good vascularization that
can lead to direct osteogenesis without an interphase of cartilage formation. The minimum requirement for pore size
is approximately 100 μm to assist in the migration requirement, cell size and transport, as a smaller pore size causes
a hypoxic condition and induces osteochondral formation before osteogenesis, while a pore size from 500 to 1000 μm
affects the differentiation of the stem cells. In addition, it was found that high porosity induces osteogenesis. The average
porosity of the scaffold for cell proliferation was between 25-50 μm. In conclusion, highly porous titanium is a useful
modern material for creating 3D structures for bone regeneration and implant fixation. |
| first_indexed | 2024-03-06T04:29:52Z |
| format | Article |
| id | ukm.eprints-15352 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:29:52Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-153522020-10-16T00:47:16Z http://journalarticle.ukm.my/15352/ 3D titanium scaffold properties and osteogenesis of stem cells Rohaya Megat Abdul Wahab, Manal Nabil Hagar, Nur Atmaliya Luchman, Farinawati Yazid, Shahrul Hisham Zainal Ariffin, Studies on porous titanium for use in dental applications have been growing due to their excellent properties such as low elastic modulus, biocompatibility and excellent strength. The porosity and pore size of titanium scaffold play an important role in bone formation. Thus, this paper reviews the properties of titanium scaffold and the relationship between the porosity and pore size of titanium with the osteogenesis of stem cells in respect of its mechanical properties and biological assessment. From this review, it was found that a pore size of less than 300 μm allows for good vascularization that can lead to direct osteogenesis without an interphase of cartilage formation. The minimum requirement for pore size is approximately 100 μm to assist in the migration requirement, cell size and transport, as a smaller pore size causes a hypoxic condition and induces osteochondral formation before osteogenesis, while a pore size from 500 to 1000 μm affects the differentiation of the stem cells. In addition, it was found that high porosity induces osteogenesis. The average porosity of the scaffold for cell proliferation was between 25-50 μm. In conclusion, highly porous titanium is a useful modern material for creating 3D structures for bone regeneration and implant fixation. Penerbit Universiti Kebangsaan Malaysia 2020-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15352/1/10.pdf Rohaya Megat Abdul Wahab, and Manal Nabil Hagar, and Nur Atmaliya Luchman, and Farinawati Yazid, and Shahrul Hisham Zainal Ariffin, (2020) 3D titanium scaffold properties and osteogenesis of stem cells. Sains Malaysiana, 49 (4). pp. 809-816. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil4_2020/KandunganJilid49Bil4_2020.html |
| spellingShingle | Rohaya Megat Abdul Wahab, Manal Nabil Hagar, Nur Atmaliya Luchman, Farinawati Yazid, Shahrul Hisham Zainal Ariffin, 3D titanium scaffold properties and osteogenesis of stem cells |
| title | 3D titanium scaffold properties and osteogenesis of stem cells |
| title_full | 3D titanium scaffold properties and osteogenesis of stem cells |
| title_fullStr | 3D titanium scaffold properties and osteogenesis of stem cells |
| title_full_unstemmed | 3D titanium scaffold properties and osteogenesis of stem cells |
| title_short | 3D titanium scaffold properties and osteogenesis of stem cells |
| title_sort | 3d titanium scaffold properties and osteogenesis of stem cells |
| url | http://journalarticle.ukm.my/15352/1/10.pdf |
| work_keys_str_mv | AT rohayamegatabdulwahab 3dtitaniumscaffoldpropertiesandosteogenesisofstemcells AT manalnabilhagar 3dtitaniumscaffoldpropertiesandosteogenesisofstemcells AT nuratmaliyaluchman 3dtitaniumscaffoldpropertiesandosteogenesisofstemcells AT farinawatiyazid 3dtitaniumscaffoldpropertiesandosteogenesisofstemcells AT shahrulhishamzainalariffin 3dtitaniumscaffoldpropertiesandosteogenesisofstemcells |