Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats
Fenitrothion (FNT) induces oxidative damage in various organs including male reproductive organ such as testis and sperm; however, its effects on the male sexual behaviours and reproductive performance remain unclear. Therefore, this study aimed to evaluate the effects of FNT administration on mal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15468/1/11.pdf |
| _version_ | 1796932262858588160 |
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| author | Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib, |
| author_facet | Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib, |
| author_sort | Nur Afizah Yusoff, |
| collection | UKM |
| description | Fenitrothion (FNT) induces oxidative damage in various organs including male reproductive organ such as testis and
sperm; however, its effects on the male sexual behaviours and reproductive performance remain unclear. Therefore,
this study aimed to evaluate the effects of FNT administration on male sexual behaviour and reproductive performance.
Fertile male Sprague-Dawley rats were randomly divided into three groups (n=8/group): Control - receiving corn
oil (1 mL kg-1); FNT-10 and FNT-20 receiving 10 and 20 mg kg-1 of FNT, respectively. FNT was administered via oral
force feeding for 28 consecutive days prior to mating with untreated female rats. After mating, the rats were sacrificed
to obtain plasma and sperm for further evaluation. Results showed that FNT-20 alone decreased AChE activity
(P<0.05) compared to the control and FNT-10. Both doses of FNT also decreased sperm quality compared to control
(P<0.05). A significant difference was found (P<0.05) for the presence of intromission and ejaculation among all
groups. The mount and intromission latencies as well as post-ejaculation interval were increased (P<0.05) in FNT
groups compared to the control group. The total mount and mount frequency were decreased (P<0.05) in FNT-10 and
FNT-20 compared to the control group. For reproductive performance, there was a significant difference (P<0.05) for
the mating and pregnancy indexes among all groups. Furthermore, both doses of FNT reduced the number of dams,
delivered pups and male pups compared to the control (P<0.05). In conclusion, FNT impaired sexual behaviour and
reproductive performance of male rats. |
| first_indexed | 2024-03-06T04:30:11Z |
| format | Article |
| id | ukm.eprints-15468 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:30:11Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-154682020-10-30T04:40:00Z http://journalarticle.ukm.my/15468/ Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib, Fenitrothion (FNT) induces oxidative damage in various organs including male reproductive organ such as testis and sperm; however, its effects on the male sexual behaviours and reproductive performance remain unclear. Therefore, this study aimed to evaluate the effects of FNT administration on male sexual behaviour and reproductive performance. Fertile male Sprague-Dawley rats were randomly divided into three groups (n=8/group): Control - receiving corn oil (1 mL kg-1); FNT-10 and FNT-20 receiving 10 and 20 mg kg-1 of FNT, respectively. FNT was administered via oral force feeding for 28 consecutive days prior to mating with untreated female rats. After mating, the rats were sacrificed to obtain plasma and sperm for further evaluation. Results showed that FNT-20 alone decreased AChE activity (P<0.05) compared to the control and FNT-10. Both doses of FNT also decreased sperm quality compared to control (P<0.05). A significant difference was found (P<0.05) for the presence of intromission and ejaculation among all groups. The mount and intromission latencies as well as post-ejaculation interval were increased (P<0.05) in FNT groups compared to the control group. The total mount and mount frequency were decreased (P<0.05) in FNT-10 and FNT-20 compared to the control group. For reproductive performance, there was a significant difference (P<0.05) for the mating and pregnancy indexes among all groups. Furthermore, both doses of FNT reduced the number of dams, delivered pups and male pups compared to the control (P<0.05). In conclusion, FNT impaired sexual behaviour and reproductive performance of male rats. Penerbit Universiti Kebangsaan Malaysia 2020-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15468/1/11.pdf Nur Afizah Yusoff, and Mahaneem Mohamed, and Siti Balkis Budin, and Izatus Shima Taib, (2020) Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats. Sains Malaysiana, 49 (6). pp. 1333-1344. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil6_2020/KandunganJilid49Bil6_2020.html |
| spellingShingle | Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib, Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title | Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title_full | Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title_fullStr | Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title_full_unstemmed | Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title_short | Fenitrothion impaired sexual behaviour and reproductive performance in male Sprague-Dawley rats |
| title_sort | fenitrothion impaired sexual behaviour and reproductive performance in male sprague dawley rats |
| url | http://journalarticle.ukm.my/15468/1/11.pdf |
| work_keys_str_mv | AT nurafizahyusoff fenitrothionimpairedsexualbehaviourandreproductiveperformanceinmalespraguedawleyrats AT mahaneemmohamed fenitrothionimpairedsexualbehaviourandreproductiveperformanceinmalespraguedawleyrats AT sitibalkisbudin fenitrothionimpairedsexualbehaviourandreproductiveperformanceinmalespraguedawleyrats AT izatusshimataib fenitrothionimpairedsexualbehaviourandreproductiveperformanceinmalespraguedawleyrats |