A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis
Ustekinumab is an anti-IL12/23 biologic agent used for treatment of psoriasis with excellent efficacy. However, there are therapeutic obstacles such as secondary failure and paradoxical event. Disease relapse upon discontinuation of therapy is common. A case series was performed on patients wi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16277/1/15_ms0426_pdf_43746.pdf |
| _version_ | 1796932436798472192 |
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| author | Rasimah Ismail, Adawiyah Jamil, Norazirah Md Nor, |
| author_facet | Rasimah Ismail, Adawiyah Jamil, Norazirah Md Nor, |
| author_sort | Rasimah Ismail, |
| collection | UKM |
| description | Ustekinumab is an anti-IL12/23 biologic agent used for treatment of psoriasis with
excellent efficacy. However, there are therapeutic obstacles such as secondary
failure and paradoxical event. Disease relapse upon discontinuation of therapy is
common. A case series was performed on patients with chronic plaque psoriasis
who received ustekinumab between 2013 to 2018 at a tertiary referral centre.
Demographics, clinical characteristics, duration of therapy, efficacy, treatment
complications, rate and pattern of relapses were determined from the patients’
medical records. Out of 8 patients, 6 (75%) patients were males. There were 6
(75%) biologic-naïve patients. Median age was 41.5 years (IQR26.8-48.3), median
duration of psoriasis was 16.5 years (IQR6.5-23.0). Median duration to achieve
Psoriasis Activity and Severity Index (PASI)75 was 16 weeks and median total
duration of treatment was 102 weeks. All patients achieved treatment success.
PASI75 at week 12 was achieved by 37.5%, a median of 16 weeks was required
to achieve at least PASI 75 but 6 (75%) attained PASI 90 by then. One patient
(12.5%) developed paradoxical event with pustular and plaques. Secondary failure
occurred in 2 (25%) patients. All patients relapsed after treatment discontinuation,
relapse occurred at median of 40 weeks. Most (71%) developed plaques on
relapse but 25% developed plaques and pustules. All but one patient required
further biological agent for treatment of relapse. Ustekinumab was efficacious in
all patients. Treatment success was achieved slightly later than standard duration.
The rare occurrences of secondary failure and paradoxical were observed. Relapse
was inevitable, new onset pustular eruptions featured in relapses. |
| first_indexed | 2024-03-06T04:32:25Z |
| format | Article |
| id | ukm.eprints-16277 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:32:25Z |
| publishDate | 2020 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-162772021-03-16T02:45:20Z http://journalarticle.ukm.my/16277/ A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis Rasimah Ismail, Adawiyah Jamil, Norazirah Md Nor, Ustekinumab is an anti-IL12/23 biologic agent used for treatment of psoriasis with excellent efficacy. However, there are therapeutic obstacles such as secondary failure and paradoxical event. Disease relapse upon discontinuation of therapy is common. A case series was performed on patients with chronic plaque psoriasis who received ustekinumab between 2013 to 2018 at a tertiary referral centre. Demographics, clinical characteristics, duration of therapy, efficacy, treatment complications, rate and pattern of relapses were determined from the patients’ medical records. Out of 8 patients, 6 (75%) patients were males. There were 6 (75%) biologic-naïve patients. Median age was 41.5 years (IQR26.8-48.3), median duration of psoriasis was 16.5 years (IQR6.5-23.0). Median duration to achieve Psoriasis Activity and Severity Index (PASI)75 was 16 weeks and median total duration of treatment was 102 weeks. All patients achieved treatment success. PASI75 at week 12 was achieved by 37.5%, a median of 16 weeks was required to achieve at least PASI 75 but 6 (75%) attained PASI 90 by then. One patient (12.5%) developed paradoxical event with pustular and plaques. Secondary failure occurred in 2 (25%) patients. All patients relapsed after treatment discontinuation, relapse occurred at median of 40 weeks. Most (71%) developed plaques on relapse but 25% developed plaques and pustules. All but one patient required further biological agent for treatment of relapse. Ustekinumab was efficacious in all patients. Treatment success was achieved slightly later than standard duration. The rare occurrences of secondary failure and paradoxical were observed. Relapse was inevitable, new onset pustular eruptions featured in relapses. Pusat Perubatan Universiti Kebangsaan Malaysia 2020-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16277/1/15_ms0426_pdf_43746.pdf Rasimah Ismail, and Adawiyah Jamil, and Norazirah Md Nor, (2020) A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis. Medicine & Health, 15 (2). pp. 153-163. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/15/2 |
| spellingShingle | Rasimah Ismail, Adawiyah Jamil, Norazirah Md Nor, A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title | A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title_full | A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title_fullStr | A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title_full_unstemmed | A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title_short | A case series exploring the efficacy, secondary failure, paradoxical event & relapse with ustekinumab therapy in chronic plaque psoriasis |
| title_sort | case series exploring the efficacy secondary failure paradoxical event relapse with ustekinumab therapy in chronic plaque psoriasis |
| url | http://journalarticle.ukm.my/16277/1/15_ms0426_pdf_43746.pdf |
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