Summary: | Lipopolysaccharide (LPS) is an important pathogenic factor for sepsis which results in cardiovascular diseases and
even mortality. Proanthocyanidin, one of the main components in grape seed, has a wide range of biological activities in
various diseases. The mouse model was established by intraperitoneal injection with LPS. Grape seed proanthocyanidin
(GSP) was administered continuously for 8 days. Our results showed that pre-treatment of GSP dramatically ameliorated
the level of creatine kinase (CK) and lactate dehydrogenase (LDH) to defend against LPS-induced myocardial toxicity
(p<0.01). Moreover, pre-treatment of GSP significantly mitigated the expression of matrix metallopeptidase 2
(MMP-2) and matrix metallopeptidase 9 (MMP-9) to inhibit LPS-induced myocardial fibrosis (p<0.01). In addition,
pre-treatment of GSP significantly increased superoxide dismutase (SOD) and catalase (CAT) activities to improve the
level of malondialdehyde (MDA) and hydrogen peroxide (H2
O2
) (p<0.01). Lastly, pre-treatment of GSP relieved tumor
necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) activities to prevent inflammatory responses (p<0.01).
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