Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice
Lipopolysaccharide (LPS) is an important pathogenic factor for sepsis which results in cardiovascular diseases and even mortality. Proanthocyanidin, one of the main components in grape seed, has a wide range of biological activities in various diseases. The mouse model was established by intrape...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17168/1/6.pdf |
| _version_ | 1796932604486746112 |
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| author | Liu, Xianchu Li, Sha Chen, Ruyan Li, Yue Liu, Ming Peng, Huan |
| author_facet | Liu, Xianchu Li, Sha Chen, Ruyan Li, Yue Liu, Ming Peng, Huan |
| author_sort | Liu, Xianchu |
| collection | UKM |
| description | Lipopolysaccharide (LPS) is an important pathogenic factor for sepsis which results in cardiovascular diseases and
even mortality. Proanthocyanidin, one of the main components in grape seed, has a wide range of biological activities in
various diseases. The mouse model was established by intraperitoneal injection with LPS. Grape seed proanthocyanidin
(GSP) was administered continuously for 8 days. Our results showed that pre-treatment of GSP dramatically ameliorated
the level of creatine kinase (CK) and lactate dehydrogenase (LDH) to defend against LPS-induced myocardial toxicity
(p<0.01). Moreover, pre-treatment of GSP significantly mitigated the expression of matrix metallopeptidase 2
(MMP-2) and matrix metallopeptidase 9 (MMP-9) to inhibit LPS-induced myocardial fibrosis (p<0.01). In addition,
pre-treatment of GSP significantly increased superoxide dismutase (SOD) and catalase (CAT) activities to improve the
level of malondialdehyde (MDA) and hydrogen peroxide (H2
O2
) (p<0.01). Lastly, pre-treatment of GSP relieved tumor
necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) activities to prevent inflammatory responses (p<0.01). |
| first_indexed | 2024-03-06T04:34:59Z |
| format | Article |
| id | ukm.eprints-17168 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:34:59Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-171682021-07-26T02:34:27Z http://journalarticle.ukm.my/17168/ Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice Liu, Xianchu Li, Sha Chen, Ruyan Li, Yue Liu, Ming Peng, Huan Lipopolysaccharide (LPS) is an important pathogenic factor for sepsis which results in cardiovascular diseases and even mortality. Proanthocyanidin, one of the main components in grape seed, has a wide range of biological activities in various diseases. The mouse model was established by intraperitoneal injection with LPS. Grape seed proanthocyanidin (GSP) was administered continuously for 8 days. Our results showed that pre-treatment of GSP dramatically ameliorated the level of creatine kinase (CK) and lactate dehydrogenase (LDH) to defend against LPS-induced myocardial toxicity (p<0.01). Moreover, pre-treatment of GSP significantly mitigated the expression of matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) to inhibit LPS-induced myocardial fibrosis (p<0.01). In addition, pre-treatment of GSP significantly increased superoxide dismutase (SOD) and catalase (CAT) activities to improve the level of malondialdehyde (MDA) and hydrogen peroxide (H2 O2 ) (p<0.01). Lastly, pre-treatment of GSP relieved tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) activities to prevent inflammatory responses (p<0.01). Penerbit Universiti Kebangsaan Malaysia 2021-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17168/1/6.pdf Liu, Xianchu and Li, Sha and Chen, Ruyan and Li, Yue and Liu, Ming and Peng, Huan (2021) Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice. Sains Malaysiana, 50 (4). pp. 945-952. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil4_2021/KandunganJilid50Bil4_2021.html |
| spellingShingle | Liu, Xianchu Li, Sha Chen, Ruyan Li, Yue Liu, Ming Peng, Huan Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title | Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title_full | Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title_fullStr | Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title_full_unstemmed | Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title_short | Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice |
| title_sort | grape seed proanthocyanidin improves lipopolysaccharide induced myocardial toxicity in mice |
| url | http://journalarticle.ukm.my/17168/1/6.pdf |
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