Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration
Acute wound cases are increasing every year. Meanwhile, current treatments have many adverse impacts; thus, alternative treatment is required. Marphysa moribidii; a local polychaete is found to has a promising potential as a wound-healing agent due to its regenerative capability. However, no prior...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
|
| Online Access: | http://journalarticle.ukm.my/17245/1/49_04_30.pdf |
| _version_ | 1796932619389108224 |
|---|---|
| author | Logeiswariy Perumal, Nor ‘Awatif Che Soh, Hannah Syahirah Rapi, Suvik Assaw, Mohammad Ameerul Amin Bakar @ Omar, Izwandy Idris, Wan Iryani Wan Ismail, |
| author_facet | Logeiswariy Perumal, Nor ‘Awatif Che Soh, Hannah Syahirah Rapi, Suvik Assaw, Mohammad Ameerul Amin Bakar @ Omar, Izwandy Idris, Wan Iryani Wan Ismail, |
| author_sort | Logeiswariy Perumal, |
| collection | UKM |
| description | Acute wound cases are increasing every year. Meanwhile, current treatments have many adverse impacts; thus, alternative
treatment is required. Marphysa moribidii; a local polychaete is found to has a promising potential as a wound-healing agent
due to its regenerative capability. However, no prior study has been conducted to prove this notion. Hence, this study is
aimed to determine the effectiveness of aqueous extract of M. moribidii in wound healing treatment. The polychaete was
finely pulverized and lyophilized by freeze-dryer to form a powdery-form extract before preparing in three different
concentrations: 0.3% (w/w), 1.0% (w/w), and 2.0% (w/w) in ointment form. The treatments including Gamat oil 0.4% (w/w)
as control were applied to the rat model once daily for 14 days. Gamat oil (0.4%) demonstrated the most rapid wound
healing, followed by polychaete ointment (0.3%). However, based on Masson’s trichrome staining, the polychaete ointment
exhibited the most collagen deposition compared to other treatments. The staining indicates a more effective healing process
of the wound after treated with the polychaete ointment. Based on the findings, polychaete extract has great potential in
wound healing; more detailed studies are needed to gain more evidences. |
| first_indexed | 2024-03-06T04:35:13Z |
| format | Article |
| id | ukm.eprints-17245 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:35:13Z |
| publishDate | 2020 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-172452021-07-29T03:55:30Z http://journalarticle.ukm.my/17245/ Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration Logeiswariy Perumal, Nor ‘Awatif Che Soh, Hannah Syahirah Rapi, Suvik Assaw, Mohammad Ameerul Amin Bakar @ Omar, Izwandy Idris, Wan Iryani Wan Ismail, Acute wound cases are increasing every year. Meanwhile, current treatments have many adverse impacts; thus, alternative treatment is required. Marphysa moribidii; a local polychaete is found to has a promising potential as a wound-healing agent due to its regenerative capability. However, no prior study has been conducted to prove this notion. Hence, this study is aimed to determine the effectiveness of aqueous extract of M. moribidii in wound healing treatment. The polychaete was finely pulverized and lyophilized by freeze-dryer to form a powdery-form extract before preparing in three different concentrations: 0.3% (w/w), 1.0% (w/w), and 2.0% (w/w) in ointment form. The treatments including Gamat oil 0.4% (w/w) as control were applied to the rat model once daily for 14 days. Gamat oil (0.4%) demonstrated the most rapid wound healing, followed by polychaete ointment (0.3%). However, based on Masson’s trichrome staining, the polychaete ointment exhibited the most collagen deposition compared to other treatments. The staining indicates a more effective healing process of the wound after treated with the polychaete ointment. Based on the findings, polychaete extract has great potential in wound healing; more detailed studies are needed to gain more evidences. Penerbit Universiti Kebangsaan Malaysia 2020 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17245/1/49_04_30.pdf Logeiswariy Perumal, and Nor ‘Awatif Che Soh, and Hannah Syahirah Rapi, and Suvik Assaw, and Mohammad Ameerul Amin Bakar @ Omar, and Izwandy Idris, and Wan Iryani Wan Ismail, (2020) Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration. Malaysian Applied Biology, 49 (4). pp. 223-231. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=1070&catid=59:current-view&Itemid=56 |
| spellingShingle | Logeiswariy Perumal, Nor ‘Awatif Che Soh, Hannah Syahirah Rapi, Suvik Assaw, Mohammad Ameerul Amin Bakar @ Omar, Izwandy Idris, Wan Iryani Wan Ismail, Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title | Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title_full | Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title_fullStr | Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title_full_unstemmed | Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title_short | Aqueous extract emulsifying ointment of Marphysa moribidii (Annelida: Polychaeta) increases collagen deposition in wound healing model at low concentration |
| title_sort | aqueous extract emulsifying ointment of marphysa moribidii annelida polychaeta increases collagen deposition in wound healing model at low concentration |
| url | http://journalarticle.ukm.my/17245/1/49_04_30.pdf |
| work_keys_str_mv | AT logeiswariyperumal aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT norawatifchesoh aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT hannahsyahirahrapi aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT suvikassaw aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT mohammadameerulaminbakaromar aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT izwandyidris aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration AT waniryaniwanismail aqueousextractemulsifyingointmentofmarphysamoribidiiannelidapolychaetaincreasescollagendepositioninwoundhealingmodelatlowconcentration |