Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in growth factors that promote stem cell differentiation and tissue regen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17537/1/19.pdf |
| _version_ | 1796932671405817856 |
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| author | Nabillah Abd Radzak, Malliga Raman Murali, Tunku Kamarul, |
| author_facet | Nabillah Abd Radzak, Malliga Raman Murali, Tunku Kamarul, |
| author_sort | Nabillah Abd Radzak, |
| collection | UKM |
| description | Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage
regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in
growth factors that promote stem cell differentiation and tissue regeneration. Despite of multiple reports available on
the use of BMC for cartilage repair in humans and its use in clinical settings, only limited number of pre-clinical proof
of concept studies have been reported in animal models. Hence, a systematic review focusing on the potential of BMC
for the treatment of cartilage defect in animal models has been conducted. The systematic search of literature using
three popular databases, ISI Web of Knowledge, PubMed and Scopus, were conducted without year restriction. Fifteen
(n = 15) studies were found appropriate and included in this review. All of the included studies were of different animal
models with cartilage defect. 13 out of 15 studies reported that the usage of BMC gave the best outcome compared to
other treatment methods. Most of the findings provided good scoring on the tissue repair and the histological outcome.
However, most of the BMC group outcomes did not give a significant difference when compared with other interventions
such as the addition of platelet rich plasma, erythropoietin, hyaluronic acid, transforming growth factor, autologous tissue
implant, genetic modification or scaffoldings. In conclusion, the published studies do suggest that BMC could provide a
better cartilage repair. However, more preclinical studies are required to provide definitive conclusions. |
| first_indexed | 2024-03-06T04:36:01Z |
| format | Article |
| id | ukm.eprints-17537 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:36:01Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-175372021-10-26T06:20:12Z http://journalarticle.ukm.my/17537/ Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review Nabillah Abd Radzak, Malliga Raman Murali, Tunku Kamarul, Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in growth factors that promote stem cell differentiation and tissue regeneration. Despite of multiple reports available on the use of BMC for cartilage repair in humans and its use in clinical settings, only limited number of pre-clinical proof of concept studies have been reported in animal models. Hence, a systematic review focusing on the potential of BMC for the treatment of cartilage defect in animal models has been conducted. The systematic search of literature using three popular databases, ISI Web of Knowledge, PubMed and Scopus, were conducted without year restriction. Fifteen (n = 15) studies were found appropriate and included in this review. All of the included studies were of different animal models with cartilage defect. 13 out of 15 studies reported that the usage of BMC gave the best outcome compared to other treatment methods. Most of the findings provided good scoring on the tissue repair and the histological outcome. However, most of the BMC group outcomes did not give a significant difference when compared with other interventions such as the addition of platelet rich plasma, erythropoietin, hyaluronic acid, transforming growth factor, autologous tissue implant, genetic modification or scaffoldings. In conclusion, the published studies do suggest that BMC could provide a better cartilage repair. However, more preclinical studies are required to provide definitive conclusions. Penerbit Universiti Kebangsaan Malaysia 2021-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17537/1/19.pdf Nabillah Abd Radzak, and Malliga Raman Murali, and Tunku Kamarul, (2021) Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review. Sains Malaysiana, 50 (6). pp. 1727-1744. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil6_2021/KandunganJilid50Bil6_2021.html |
| spellingShingle | Nabillah Abd Radzak, Malliga Raman Murali, Tunku Kamarul, Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title | Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title_full | Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title_fullStr | Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title_full_unstemmed | Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title_short | Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review |
| title_sort | assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models a systemic review |
| url | http://journalarticle.ukm.my/17537/1/19.pdf |
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