Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne

Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported....

Full description

Bibliographic Details
Main Authors: Dini, Iwan, Soekamto, Nunuk Hariani, Firdaus, Supratman, Unang, Jalifah Latip
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/18063/1/14.pdf
_version_ 1796932772262051840
author Dini, Iwan
Soekamto, Nunuk Hariani
Firdaus,
Supratman, Unang
Jalifah Latip,
author_facet Dini, Iwan
Soekamto, Nunuk Hariani
Firdaus,
Supratman, Unang
Jalifah Latip,
author_sort Dini, Iwan
collection UKM
description Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 μg/mL.
first_indexed 2024-03-06T04:37:29Z
format Article
id ukm.eprints-18063
institution Universiti Kebangsaan Malaysia
language English
last_indexed 2024-03-06T04:37:29Z
publishDate 2021
publisher Penerbit Universiti Kebangsaan Malaysia
record_format dspace
spelling ukm.eprints-180632022-02-18T00:48:17Z http://journalarticle.ukm.my/18063/ Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne Dini, Iwan Soekamto, Nunuk Hariani Firdaus, Supratman, Unang Jalifah Latip, Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 μg/mL. Penerbit Universiti Kebangsaan Malaysia 2021-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18063/1/14.pdf Dini, Iwan and Soekamto, Nunuk Hariani and Firdaus, and Supratman, Unang and Jalifah Latip, (2021) Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne. Sains Malaysiana, 50 (9). pp. 2663-2674. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil9_2021/KandunganJilid50Bil9_2021.html
spellingShingle Dini, Iwan
Soekamto, Nunuk Hariani
Firdaus,
Supratman, Unang
Jalifah Latip,
Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title_full Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title_fullStr Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title_full_unstemmed Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title_short Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
title_sort alkaloid caulerpin and cytotoxic activity against ncl h460 lung cancer cells isolated along with β sitosterol from the halimeda cylindracea decaisne
url http://journalarticle.ukm.my/18063/1/14.pdf
work_keys_str_mv AT diniiwan alkaloidcaulerpinandcytotoxicactivityagainstnclh460lungcancercellsisolatedalongwithbsitosterolfromthehalimedacylindraceadecaisne
AT soekamtonunukhariani alkaloidcaulerpinandcytotoxicactivityagainstnclh460lungcancercellsisolatedalongwithbsitosterolfromthehalimedacylindraceadecaisne
AT firdaus alkaloidcaulerpinandcytotoxicactivityagainstnclh460lungcancercellsisolatedalongwithbsitosterolfromthehalimedacylindraceadecaisne
AT supratmanunang alkaloidcaulerpinandcytotoxicactivityagainstnclh460lungcancercellsisolatedalongwithbsitosterolfromthehalimedacylindraceadecaisne
AT jalifahlatip alkaloidcaulerpinandcytotoxicactivityagainstnclh460lungcancercellsisolatedalongwithbsitosterolfromthehalimedacylindraceadecaisne