A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models
Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18825/1/151-156%2B%2B%2BTuan%2BSalwani%2BTuan%2BIsmail.pdf |
| _version_ | 1796932927015092224 |
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| author | Anis Farihan Ismail, Suriati Mohd Nasir, Tuan Salwani Tuan Ismail, Wan Amir Nizam Wan Ahmad, Wan Faiziah Wan Abdul Rahman, Kuttulebbai Nainamohammed Salam Sirajudeen, Tengku Ahmad Damitri Al- Astani Tengku Din, |
| author_facet | Anis Farihan Ismail, Suriati Mohd Nasir, Tuan Salwani Tuan Ismail, Wan Amir Nizam Wan Ahmad, Wan Faiziah Wan Abdul Rahman, Kuttulebbai Nainamohammed Salam Sirajudeen, Tengku Ahmad Damitri Al- Astani Tengku Din, |
| author_sort | Anis Farihan Ismail, |
| collection | UKM |
| description | Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both.
SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus
(DM). Since the role of SBH in glucose control is still unclear in animal and human studies, the present study was designed
to evaluate the antihyperglycemic effects of SBH in streptozotocin-induced diabetic rat models. Fifteen Sprague-Dawley
rats (200-250 g) were equally divided into five groups, the first group being a normal (non-diabetic) rat and the other four
groups being diabetic. The normal and untreated diabetic groups received normal saline while the other diabetic groups
were treated with SBH (2 g/kg body weight), metformin (MET /250 mg/kg body weight) and SBH + MET respectively.
The treatment was given within 12 days. Fasting blood glucose (FBG) was measured at baseline and every two weeks
thereafter. On days 7 and 12, SBH significantly lowered FBG, comparable to the normal group (p<0.05). In the group
treated with MET and the combination of SBH-MET, FBG improved only on the 12th day of treatment (p<0.05). The
results show that a single SBH treatment is effective in lowering blood glucose levels. Thus, SBH could be of great value in
the treatment of diabetes in humans. |
| first_indexed | 2024-03-06T04:39:40Z |
| format | Article |
| id | ukm.eprints-18825 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:39:40Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-188252022-06-24T00:59:49Z http://journalarticle.ukm.my/18825/ A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models Anis Farihan Ismail, Suriati Mohd Nasir, Tuan Salwani Tuan Ismail, Wan Amir Nizam Wan Ahmad, Wan Faiziah Wan Abdul Rahman, Kuttulebbai Nainamohammed Salam Sirajudeen, Tengku Ahmad Damitri Al- Astani Tengku Din, Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is still unclear in animal and human studies, the present study was designed to evaluate the antihyperglycemic effects of SBH in streptozotocin-induced diabetic rat models. Fifteen Sprague-Dawley rats (200-250 g) were equally divided into five groups, the first group being a normal (non-diabetic) rat and the other four groups being diabetic. The normal and untreated diabetic groups received normal saline while the other diabetic groups were treated with SBH (2 g/kg body weight), metformin (MET /250 mg/kg body weight) and SBH + MET respectively. The treatment was given within 12 days. Fasting blood glucose (FBG) was measured at baseline and every two weeks thereafter. On days 7 and 12, SBH significantly lowered FBG, comparable to the normal group (p<0.05). In the group treated with MET and the combination of SBH-MET, FBG improved only on the 12th day of treatment (p<0.05). The results show that a single SBH treatment is effective in lowering blood glucose levels. Thus, SBH could be of great value in the treatment of diabetes in humans. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18825/1/151-156%2B%2B%2BTuan%2BSalwani%2BTuan%2BIsmail.pdf Anis Farihan Ismail, and Suriati Mohd Nasir, and Tuan Salwani Tuan Ismail, and Wan Amir Nizam Wan Ahmad, and Wan Faiziah Wan Abdul Rahman, and Kuttulebbai Nainamohammed Salam Sirajudeen, and Tengku Ahmad Damitri Al- Astani Tengku Din, (2021) A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models. Malaysian Applied Biology, 50 (2). pp. 151-156. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/36 |
| spellingShingle | Anis Farihan Ismail, Suriati Mohd Nasir, Tuan Salwani Tuan Ismail, Wan Amir Nizam Wan Ahmad, Wan Faiziah Wan Abdul Rahman, Kuttulebbai Nainamohammed Salam Sirajudeen, Tengku Ahmad Damitri Al- Astani Tengku Din, A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title | A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title_full | A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title_fullStr | A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title_full_unstemmed | A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title_short | A preliminary study on the effects of stingless bee honey (SBH) on fasting blood glucose in streptozotocin (STZ)-induced diabetic rat models |
| title_sort | preliminary study on the effects of stingless bee honey sbh on fasting blood glucose in streptozotocin stz induced diabetic rat models |
| url | http://journalarticle.ukm.my/18825/1/151-156%2B%2B%2BTuan%2BSalwani%2BTuan%2BIsmail.pdf |
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