Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells
Senescence-induced therapy has been improved to increase its cytotoxicity and reduce the resistance of breast cancer cells to chemotherapy agents. An example of a potential senescence-inducing agent is black cumin oil (BCO) because one of its major compounds, α-pinene, can induce senescent cells....
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/19514/1/9%2B-%2BBLACK%2BCUMIN%2BOIL%2BEFFECT%2BON%2BSENESCENCE%2BOF%2BHER-2-BREAST%2BCANCER%2BCELLS.pdf |
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| author | Faradiba Nur Ahlina, Lisyaratih Anggriani, Irfani Aura Salsabila, Riris Istighfari Jenie, |
| author_facet | Faradiba Nur Ahlina, Lisyaratih Anggriani, Irfani Aura Salsabila, Riris Istighfari Jenie, |
| author_sort | Faradiba Nur Ahlina, |
| collection | UKM |
| description | Senescence-induced therapy has been improved to increase its cytotoxicity and reduce the resistance of breast cancer cells to
chemotherapy agents. An example of a potential senescence-inducing agent is black cumin oil (BCO) because one of its major
compounds, α-pinene, can induce senescent cells. This study aims to explore the senescence-inducing activity of BCO in
HER2-overexpressing breast cancer cells (MCF7/HER2). The yield obtained from hydro-distillation of BCO was 0.54%, and
the main compounds were p-cymene (48.03%), dihydrocarveol (11.39%), and α-pinene (11.29%). BCO exhibited a moderate
cytotoxicity profile indicated by IC50, which was >200 μg/mL in both cell lines. In combination with doxorubicin, BCO did not
increase the cytotoxicity of doxorubicin. Moreover, BCO induced senescence by increasing 3% of the senescent cells compared
with that of the untreated cells. A combination of BCO and doxorubicin increased the senescent cells by 3%–7% compared
with doxorubicin alone. Therefore, the moderate cytotoxicity of BCO could be beneficial to the application of BCO as a
chemotherapeutic adjuvant which increases cancer cells senescent and consequently inhibits cell proliferation. |
| first_indexed | 2024-03-06T04:41:42Z |
| format | Article |
| id | ukm.eprints-19514 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:41:42Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-195142022-08-30T00:57:36Z http://journalarticle.ukm.my/19514/ Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells Faradiba Nur Ahlina, Lisyaratih Anggriani, Irfani Aura Salsabila, Riris Istighfari Jenie, Senescence-induced therapy has been improved to increase its cytotoxicity and reduce the resistance of breast cancer cells to chemotherapy agents. An example of a potential senescence-inducing agent is black cumin oil (BCO) because one of its major compounds, α-pinene, can induce senescent cells. This study aims to explore the senescence-inducing activity of BCO in HER2-overexpressing breast cancer cells (MCF7/HER2). The yield obtained from hydro-distillation of BCO was 0.54%, and the main compounds were p-cymene (48.03%), dihydrocarveol (11.39%), and α-pinene (11.29%). BCO exhibited a moderate cytotoxicity profile indicated by IC50, which was >200 μg/mL in both cell lines. In combination with doxorubicin, BCO did not increase the cytotoxicity of doxorubicin. Moreover, BCO induced senescence by increasing 3% of the senescent cells compared with that of the untreated cells. A combination of BCO and doxorubicin increased the senescent cells by 3%–7% compared with doxorubicin alone. Therefore, the moderate cytotoxicity of BCO could be beneficial to the application of BCO as a chemotherapeutic adjuvant which increases cancer cells senescent and consequently inhibits cell proliferation. Penerbit Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19514/1/9%2B-%2BBLACK%2BCUMIN%2BOIL%2BEFFECT%2BON%2BSENESCENCE%2BOF%2BHER-2-BREAST%2BCANCER%2BCELLS.pdf Faradiba Nur Ahlina, and Lisyaratih Anggriani, and Irfani Aura Salsabila, and Riris Istighfari Jenie, (2022) Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells. Malaysian Applied Biology, 51 (1). pp. 91-97. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/44 |
| spellingShingle | Faradiba Nur Ahlina, Lisyaratih Anggriani, Irfani Aura Salsabila, Riris Istighfari Jenie, Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title | Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title_full | Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title_fullStr | Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title_full_unstemmed | Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title_short | Bioactivity of black cumin oil on the senescence of HER-2-overexpressing breast cancer cells |
| title_sort | bioactivity of black cumin oil on the senescence of her 2 overexpressing breast cancer cells |
| url | http://journalarticle.ukm.my/19514/1/9%2B-%2BBLACK%2BCUMIN%2BOIL%2BEFFECT%2BON%2BSENESCENCE%2BOF%2BHER-2-BREAST%2BCANCER%2BCELLS.pdf |
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