Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel
Discontinuing antihistamines for patch testing (PT) in allergic contact dermatitis (ACD) is more conventional than evidence based. Data suggests that non-sedating antihistamines do not interfere with PT. Investigating the effects of sedating antihistamines are more relevant as these are recommend...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
|
| Online Access: | http://journalarticle.ukm.my/20200/1/7_ms0167_pdf_17766.pdf |
| _version_ | 1796933207301554176 |
|---|---|
| author | Shafinaz S, Adawiyah Jamil, Chan, LC Norazirah MN, |
| author_facet | Shafinaz S, Adawiyah Jamil, Chan, LC Norazirah MN, |
| author_sort | Shafinaz S, |
| collection | UKM |
| description | Discontinuing antihistamines for patch testing (PT) in allergic contact dermatitis
(ACD) is more conventional than evidence based. Data suggests that non-sedating
antihistamines do not interfere with PT. Investigating the effects of sedating
antihistamines are more relevant as these are recommended for eczema. We aimed
to evaluate the effect of chlorpheniramine on PT, to determine the prevalence of
nickel sensitization and common sensitizing allergens. An open labeled cohort study
was conducted at two dermatology clinics. Patients indicated for PT underwent
standard protocol where antihistamines were discontinued. Patients sensitised to
nickel were subjected to a second nickel PT while taking chlorpheniramine. Results
were evaluated using the North American Contact Dermatitis Research Group
(NACDRG) score, a Mexameter measured erythema and pruritus was assessed
using a visual analogue score. A total 82 patients were recruited, 28 (34.1%) were
sensitised to nickel. The mean age was 40 ± 17.7 years with 22(26.8%) males and
60 (73.2%) females. Indications for PT included suspected ACD (57.3%), hand
and feet eczema (34.1%) and severe eczema with suspected superimposed ACD
(6.1%). The commonest sensitizing allergens were methyldibromoglutaronitrile
(40.2%) nickel sulphate (34.1%), potassium dichromate (29.3%) and formaldehyde
(24.4%). A second PT was performed on 23 patients. There was no difference in the
NACDRG score with chlorpheniramine or without chlorpheniramine (p=0.968).
Pruritus score was reduced by 1.39 ± 2.9, p=0.031 with chlorpheniramine. The
degree of erythema was 611.46 ± 21.59 with chlorpheniramine versus 613.87 ±
27.5 without chlorpheniramine, p=0.671. Chlorpheniramine did not affect PT
based on clinical and objective scorings. It has the additional benefit of reducing
test-induced itch. |
| first_indexed | 2024-03-06T04:43:41Z |
| format | Article |
| id | ukm.eprints-20200 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:43:41Z |
| publishDate | 2018 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-202002022-10-21T08:17:17Z http://journalarticle.ukm.my/20200/ Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel Shafinaz S, Adawiyah Jamil, Chan, LC Norazirah MN, Discontinuing antihistamines for patch testing (PT) in allergic contact dermatitis (ACD) is more conventional than evidence based. Data suggests that non-sedating antihistamines do not interfere with PT. Investigating the effects of sedating antihistamines are more relevant as these are recommended for eczema. We aimed to evaluate the effect of chlorpheniramine on PT, to determine the prevalence of nickel sensitization and common sensitizing allergens. An open labeled cohort study was conducted at two dermatology clinics. Patients indicated for PT underwent standard protocol where antihistamines were discontinued. Patients sensitised to nickel were subjected to a second nickel PT while taking chlorpheniramine. Results were evaluated using the North American Contact Dermatitis Research Group (NACDRG) score, a Mexameter measured erythema and pruritus was assessed using a visual analogue score. A total 82 patients were recruited, 28 (34.1%) were sensitised to nickel. The mean age was 40 ± 17.7 years with 22(26.8%) males and 60 (73.2%) females. Indications for PT included suspected ACD (57.3%), hand and feet eczema (34.1%) and severe eczema with suspected superimposed ACD (6.1%). The commonest sensitizing allergens were methyldibromoglutaronitrile (40.2%) nickel sulphate (34.1%), potassium dichromate (29.3%) and formaldehyde (24.4%). A second PT was performed on 23 patients. There was no difference in the NACDRG score with chlorpheniramine or without chlorpheniramine (p=0.968). Pruritus score was reduced by 1.39 ± 2.9, p=0.031 with chlorpheniramine. The degree of erythema was 611.46 ± 21.59 with chlorpheniramine versus 613.87 ± 27.5 without chlorpheniramine, p=0.671. Chlorpheniramine did not affect PT based on clinical and objective scorings. It has the additional benefit of reducing test-induced itch. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20200/1/7_ms0167_pdf_17766.pdf Shafinaz S, and Adawiyah Jamil, and Chan, LC and Norazirah MN, (2018) Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel. Medicine & Health, 13 (1). pp. 71-76. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/1 |
| spellingShingle | Shafinaz S, Adawiyah Jamil, Chan, LC Norazirah MN, Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title | Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title_full | Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title_fullStr | Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title_full_unstemmed | Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title_short | Evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| title_sort | evaluating the effect of chlorpheniramine on patch test reactions amongst eczema patients sensitised to nickel |
| url | http://journalarticle.ukm.my/20200/1/7_ms0167_pdf_17766.pdf |
| work_keys_str_mv | AT shafinazs evaluatingtheeffectofchlorpheniramineonpatchtestreactionsamongsteczemapatientssensitisedtonickel AT adawiyahjamil evaluatingtheeffectofchlorpheniramineonpatchtestreactionsamongsteczemapatientssensitisedtonickel AT chanlc evaluatingtheeffectofchlorpheniramineonpatchtestreactionsamongsteczemapatientssensitisedtonickel AT norazirahmn evaluatingtheeffectofchlorpheniramineonpatchtestreactionsamongsteczemapatientssensitisedtonickel |