Evaluation of outer retinal layers in diabetic macula edema treated with intravitreal ranibizumab
Anti-vascular endothelial growth factor (VEGF) reduces choroidal thickness by choroidal hypoperfusion in diabetic macula oedema (DME) patients. Indirect effect of anti-VEGF towards outer retinal layers (ORL) which supplied by choroidal circulation has not been well described. We evaluate the ORL...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/20202/1/9_ms0170_pdf_12766.pdf |
| Summary: | Anti-vascular endothelial growth factor (VEGF) reduces choroidal thickness by
choroidal hypoperfusion in diabetic macula oedema (DME) patients. Indirect
effect of anti-VEGF towards outer retinal layers (ORL) which supplied by choroidal
circulation has not been well described. We evaluate the ORL thickness between
retinal pigment epithelium (RPE) with inner-segment-outer-segment photoreceptor
junction (IS/OS) and RPE with external limiting membrane (ELM) in pre- and postintravitreal
Ranibizumab (IVR) treated eyes with central foveal diabetic macula
edema. A total of 60 eyes (40 patients) were analysed. ORL thickness measured
with optical coherence tomography at pre- and post-injection day 1, week 4
and week 6. Mean thickness of RPE-IS/OS was statistically significant over time
(p=0.023) but not for RPE-ELM (p=0.216). Thickness ratio between RPE-IS/OS and
RPE-ELM and central subfoveal thickness (CST) both showed statistically significant
result over time with p=0.038 and p=0.000, respectively. We observed an initial
reduction of ORL thickness at day 1 followed by increased in thickness at week
4 with subsequent reduction at week 6 was observed. ORL is an aspect that can
be explore and emphasized further in patients considered for IVR injections. The
long-term effects of IVR to the ORL however could not be concluded due to short
follow up period. |
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