Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglyceri...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/21623/1/SD%2020.pdf |
| _version_ | 1796933463938433024 |
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| author | Maulana, Harfi Ridwan, Ahmad Suprijanto, Kusumawardani, Shanty Rahayu Fitri, Lulu Lusianti |
| author_facet | Maulana, Harfi Ridwan, Ahmad Suprijanto, Kusumawardani, Shanty Rahayu Fitri, Lulu Lusianti |
| author_sort | Maulana, Harfi |
| collection | UKM |
| description | Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglycerides with low concentrations of HDL. A high-fat diet (HFD) contributes to the progression of atherosclerosis, CHD, and other cardiovascular diseases. This study aims to measure electrocardiography (ECG) waves of hyperlipidemia-induced rats. Twenty rats were fed different diets for eight weeks, i.e., the control group (normal diet) and the HFD group (high-fat diet). Their ECG was recorded using a Wireless Mice Electrocardiogram (WIM ECG) for 5-10 min. After eight weeks, the HFD group showed a significantly higher lipid profile concentration (cholesterol: 179.03 mg/dL, triglyceride: 149.11 mg/dL, LDL: 123 mg/dL, HDL: 29.15 mg/dL) than the control. This hyperlipidemic condition causes a significant change in some characteristics of the ECG wave. At week 8, the characteristic ECG wave duration for the HFD groups was RR intervals (176.5 ms), QT intervals (123.5 ms), T waves (33.6 ms), P wave (27.4 ms), QRS interval (64.9 ms), ST-segment (23.7 ms), and heart rate (334 bpm). This study concludes that long-period HFD feeding in rats leads to hyperlipidemia and causes changes in the characteristics of ECG waves. |
| first_indexed | 2024-03-06T04:47:36Z |
| format | Article |
| id | ukm.eprints-21623 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:47:36Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-216232023-05-23T03:56:16Z http://journalarticle.ukm.my/21623/ Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram Maulana, Harfi Ridwan, Ahmad Suprijanto, Kusumawardani, Shanty Rahayu Fitri, Lulu Lusianti Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglycerides with low concentrations of HDL. A high-fat diet (HFD) contributes to the progression of atherosclerosis, CHD, and other cardiovascular diseases. This study aims to measure electrocardiography (ECG) waves of hyperlipidemia-induced rats. Twenty rats were fed different diets for eight weeks, i.e., the control group (normal diet) and the HFD group (high-fat diet). Their ECG was recorded using a Wireless Mice Electrocardiogram (WIM ECG) for 5-10 min. After eight weeks, the HFD group showed a significantly higher lipid profile concentration (cholesterol: 179.03 mg/dL, triglyceride: 149.11 mg/dL, LDL: 123 mg/dL, HDL: 29.15 mg/dL) than the control. This hyperlipidemic condition causes a significant change in some characteristics of the ECG wave. At week 8, the characteristic ECG wave duration for the HFD groups was RR intervals (176.5 ms), QT intervals (123.5 ms), T waves (33.6 ms), P wave (27.4 ms), QRS interval (64.9 ms), ST-segment (23.7 ms), and heart rate (334 bpm). This study concludes that long-period HFD feeding in rats leads to hyperlipidemia and causes changes in the characteristics of ECG waves. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21623/1/SD%2020.pdf Maulana, Harfi and Ridwan, Ahmad and Suprijanto, and Kusumawardani, Shanty Rahayu and Fitri, Lulu Lusianti (2023) Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram. Sains Malaysiana, 52 (2). pp. 589-597. ISSN 0126-6039 http://www.ukm.my/jsm/index.html |
| spellingShingle | Maulana, Harfi Ridwan, Ahmad Suprijanto, Kusumawardani, Shanty Rahayu Fitri, Lulu Lusianti Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title | Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title_full | Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title_fullStr | Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title_full_unstemmed | Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title_short | Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram |
| title_sort | electrocardiogram analysis of hyperlipidemia induced wistar rats using wireless mice electrocardiogram |
| url | http://journalarticle.ukm.my/21623/1/SD%2020.pdf |
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