Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method
Diabetes mellitus is a chronic disorder that causes elevated blood glucose levels due to a lack of insulin, either completely or partially. We investigated the antidiabetic property of Actinodaphne angustifolia in a rat model and identified the bioactive phytochemicals by using the UPLC-QTOF/ESI-MS...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/22573/2/m%26h_10.pdf |
| _version_ | 1796933631249219584 |
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| author | F, Md. Shaekh WI, Wan Maznah MA, Mohd Fadhlizil Fasihi A, Shihab Uddin R, Kamrul T, Saiful Nizam H, Akm Moyeenul |
| author_facet | F, Md. Shaekh WI, Wan Maznah MA, Mohd Fadhlizil Fasihi A, Shihab Uddin R, Kamrul T, Saiful Nizam H, Akm Moyeenul |
| author_sort | F, Md. Shaekh |
| collection | UKM |
| description | Diabetes mellitus is a chronic disorder that causes elevated blood glucose levels due to a lack of insulin, either completely or partially. We investigated the antidiabetic property of Actinodaphne angustifolia in a rat model and identified the bioactive phytochemicals by using the UPLC-QTOF/ESI-MS method. The rats’ pancreatic structures, lipid profile and blood glucose were assessed after a one-week intervention. UPLC-QTOF/ESI-MS analysis was conducted to identify flavonoids and terpenoids in the leaf extract. Actinodaphne angustifolia extract markedly increased the high-density lipoprotein (HDL) (p<0.05) while reducing total cholesterol (TC), low-density lipoprotein (LDL) and blood glucose. Furthermore, the tissue architecture of pancreatic islets was also well recovered as compared to the control group. A total of 45 flavonoids and 109 terpenoid compounds were identified using UPLC-QTOF/ESI-MS-based analysis and additional studies should be undertaken to identify the potential antidiabetic agents. |
| first_indexed | 2024-03-06T04:50:11Z |
| format | Article |
| id | ukm.eprints-22573 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:50:11Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-225732023-11-30T07:03:08Z http://journalarticle.ukm.my/22573/ Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method F, Md. Shaekh WI, Wan Maznah MA, Mohd Fadhlizil Fasihi A, Shihab Uddin R, Kamrul T, Saiful Nizam H, Akm Moyeenul Diabetes mellitus is a chronic disorder that causes elevated blood glucose levels due to a lack of insulin, either completely or partially. We investigated the antidiabetic property of Actinodaphne angustifolia in a rat model and identified the bioactive phytochemicals by using the UPLC-QTOF/ESI-MS method. The rats’ pancreatic structures, lipid profile and blood glucose were assessed after a one-week intervention. UPLC-QTOF/ESI-MS analysis was conducted to identify flavonoids and terpenoids in the leaf extract. Actinodaphne angustifolia extract markedly increased the high-density lipoprotein (HDL) (p<0.05) while reducing total cholesterol (TC), low-density lipoprotein (LDL) and blood glucose. Furthermore, the tissue architecture of pancreatic islets was also well recovered as compared to the control group. A total of 45 flavonoids and 109 terpenoid compounds were identified using UPLC-QTOF/ESI-MS-based analysis and additional studies should be undertaken to identify the potential antidiabetic agents. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22573/2/m%26h_10.pdf F, Md. Shaekh and WI, Wan Maznah and MA, Mohd Fadhlizil Fasihi and A, Shihab Uddin and R, Kamrul and T, Saiful Nizam and H, Akm Moyeenul (2023) Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method. Medicine & Health, 18 (1). pp. 117-135. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/18/1 |
| spellingShingle | F, Md. Shaekh WI, Wan Maznah MA, Mohd Fadhlizil Fasihi A, Shihab Uddin R, Kamrul T, Saiful Nizam H, Akm Moyeenul Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title | Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title_full | Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title_fullStr | Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title_full_unstemmed | Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title_short | Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method |
| title_sort | antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using uplc qtof esi ms method |
| url | http://journalarticle.ukm.my/22573/2/m%26h_10.pdf |
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