A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King
Polyalthia bullata King’s root yielded a new compound named 5-methylliridine (1) in addition to six previously identified compounds. These known compounds include liriodenine (2), 11-methoxyliriodenine (3), lysicamine (4), onychine (5), 5-hydroxy-6-methoxyonychine (6), and 8-methoxyeupolauridine (7)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://journalarticle.ukm.my/23648/1/SDD%2010.pdf |
| _version_ | 1811136832302219264 |
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| author | Primus, Phoebe Sussana Wu, Carol Hsin-Yi Kao, Chai-Lin Choo, Yeun-Mun |
| author_facet | Primus, Phoebe Sussana Wu, Carol Hsin-Yi Kao, Chai-Lin Choo, Yeun-Mun |
| author_sort | Primus, Phoebe Sussana |
| collection | UKM |
| description | Polyalthia bullata King’s root yielded a new compound named 5-methylliridine (1) in addition to six previously identified compounds. These known compounds include liriodenine (2), 11-methoxyliriodenine (3), lysicamine (4), onychine (5), 5-hydroxy-6-methoxyonychine (6), and 8-methoxyeupolauridine (7). The structures of compounds 1-7 were determined through spectroscopic analysis. Liriodenine (2) exhibited a remarkable ability to decrease the cell viability of cancerous N2A cells to 22% within a 24 h timeframe, indicating its potential as an anti-neuroblastoma agent. Molecular docking results additionally suggested that oxoaporphines (1-4) have the potential to act as inhibitors of protein kinases. These findings highlight the therapeutic potential of P. bullata constituents in cancer treatment, particularly neuroblastoma, and contribute to understanding its medicinal properties. |
| first_indexed | 2024-09-24T01:27:20Z |
| format | Article |
| id | ukm.eprints-23648 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-09-24T01:27:20Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-236482024-06-10T08:44:10Z http://journalarticle.ukm.my/23648/ A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King Primus, Phoebe Sussana Wu, Carol Hsin-Yi Kao, Chai-Lin Choo, Yeun-Mun Polyalthia bullata King’s root yielded a new compound named 5-methylliridine (1) in addition to six previously identified compounds. These known compounds include liriodenine (2), 11-methoxyliriodenine (3), lysicamine (4), onychine (5), 5-hydroxy-6-methoxyonychine (6), and 8-methoxyeupolauridine (7). The structures of compounds 1-7 were determined through spectroscopic analysis. Liriodenine (2) exhibited a remarkable ability to decrease the cell viability of cancerous N2A cells to 22% within a 24 h timeframe, indicating its potential as an anti-neuroblastoma agent. Molecular docking results additionally suggested that oxoaporphines (1-4) have the potential to act as inhibitors of protein kinases. These findings highlight the therapeutic potential of P. bullata constituents in cancer treatment, particularly neuroblastoma, and contribute to understanding its medicinal properties. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23648/1/SDD%2010.pdf Primus, Phoebe Sussana and Wu, Carol Hsin-Yi and Kao, Chai-Lin and Choo, Yeun-Mun (2024) A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King. Sains Malaysiana, 53 (2). pp. 359-367. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num2_2024/contentsVol53num2_2024.html |
| spellingShingle | Primus, Phoebe Sussana Wu, Carol Hsin-Yi Kao, Chai-Lin Choo, Yeun-Mun A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title | A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title_full | A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title_fullStr | A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title_full_unstemmed | A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title_short | A new oxoaporphine and liriodenine’s anti-neuroblastoma potential from the roots of Polyalthia bullata King |
| title_sort | new oxoaporphine and liriodenine s anti neuroblastoma potential from the roots of polyalthia bullata king |
| url | http://journalarticle.ukm.my/23648/1/SDD%2010.pdf |
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