Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)

In this study, the effect of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities, kidney and liver functions in High Fat Diet (HFD)-induced obese rats was investigated. Thirty male Sprague–Dawley rats were divided into control negative (CN) fed with rat pellet; contro...

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Main Authors:	Ayub Mohd Yatim, Norazmir Md Nor
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2465/1/10_Ayub.pdf

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author	Ayub Mohd Yatim, Norazmir Md Nor,
author_facet	Ayub Mohd Yatim, Norazmir Md Nor,
author_sort	Ayub Mohd Yatim,
collection	UKM
description	In this study, the effect of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities, kidney and liver functions in High Fat Diet (HFD)-induced obese rats was investigated. Thirty male Sprague–Dawley rats were divided into control negative (CN) fed with rat pellet; control positive, low, medium and high dose group (CP, LDG, MDG and HDG) were fed High Fat Diet-AIN93G, respectively. CN and CP were given distilled water; while the treated group were given the aqueous puree, at concentration of 500, 1000 and 2000 mg/kg body weight, dissolved in distilled water were administered orally via a drinking bottle, respectively. Pink guava puree was supplemented with the HFD diet for six weeks. The rats were fasted overnight and euthanized under an anesthetic condition with ethyl ether, and blood was collected from the posterior vena cava at the end of experiment. A significant reduction in body weight was observed in the treated groups as compared to CN and CP group. Specific activities of glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD) of the HFD-induced obese rats were significantly increased in comparison with the CN group. Kidney function test of urea concentration were significantly decreased in HFD-induced obese rats; LDG (4.28±0.69 mmol/L), MDG (4.35±0.87 mmol/L) and HDG (3.85±0.71 mmol/L) as compared to CN (7.02±1.81 mmol/L), respectively. Liver function tests for total protein, globulin, A:G ratio and alanine aminotransferase (ALT) showed significant differences in the treated group compared to CN group. Total protein of MDG (72.67±3.65 g/L) and HDG (76.00±2.49 g/L) were significantly lower compared to CN (80.11±1.98 g/L). Globulin value for LDG (34.17±3.43 g/L), MDG (32.17±1.83 g/L) and HDG (35.00±3.41 g/L) were significantly lower compared to CN (39.67±0.82 g/L). A:G ratio LDG (1.22±0.16), MDG (1.28±0.07) and HDG (1.19±0.14) significantly different compared to CN (1.03±0.08). ALT value for LDG (55.83±15.12 U/L), MDG (50.67±22.65 U/L) and HDG (57.50±8.48 U/L) were significantly lower compared to CN (77.00±16.26 U/L), respectively. In conclusion, pink guava puree supplements seem to be beneficial for increased antioxidant enzyme activities and correcting/ preventing obesity complications in kidney and liver functions
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format	Article
id	ukm.eprints-2465
institution	Universiti Kebangsaan Malaysia
language	English
last_indexed	2024-03-06T03:46:21Z
publishDate	2011
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spelling	ukm.eprints-24652016-12-14T06:31:42Z http://journalarticle.ukm.my/2465/ Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati) Ayub Mohd Yatim, Norazmir Md Nor, In this study, the effect of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities, kidney and liver functions in High Fat Diet (HFD)-induced obese rats was investigated. Thirty male Sprague–Dawley rats were divided into control negative (CN) fed with rat pellet; control positive, low, medium and high dose group (CP, LDG, MDG and HDG) were fed High Fat Diet-AIN93G, respectively. CN and CP were given distilled water; while the treated group were given the aqueous puree, at concentration of 500, 1000 and 2000 mg/kg body weight, dissolved in distilled water were administered orally via a drinking bottle, respectively. Pink guava puree was supplemented with the HFD diet for six weeks. The rats were fasted overnight and euthanized under an anesthetic condition with ethyl ether, and blood was collected from the posterior vena cava at the end of experiment. A significant reduction in body weight was observed in the treated groups as compared to CN and CP group. Specific activities of glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD) of the HFD-induced obese rats were significantly increased in comparison with the CN group. Kidney function test of urea concentration were significantly decreased in HFD-induced obese rats; LDG (4.28±0.69 mmol/L), MDG (4.35±0.87 mmol/L) and HDG (3.85±0.71 mmol/L) as compared to CN (7.02±1.81 mmol/L), respectively. Liver function tests for total protein, globulin, A:G ratio and alanine aminotransferase (ALT) showed significant differences in the treated group compared to CN group. Total protein of MDG (72.67±3.65 g/L) and HDG (76.00±2.49 g/L) were significantly lower compared to CN (80.11±1.98 g/L). Globulin value for LDG (34.17±3.43 g/L), MDG (32.17±1.83 g/L) and HDG (35.00±3.41 g/L) were significantly lower compared to CN (39.67±0.82 g/L). A:G ratio LDG (1.22±0.16), MDG (1.28±0.07) and HDG (1.19±0.14) significantly different compared to CN (1.03±0.08). ALT value for LDG (55.83±15.12 U/L), MDG (50.67±22.65 U/L) and HDG (57.50±8.48 U/L) were significantly lower compared to CN (77.00±16.26 U/L), respectively. In conclusion, pink guava puree supplements seem to be beneficial for increased antioxidant enzyme activities and correcting/ preventing obesity complications in kidney and liver functions Universiti Kebangsaan Malaysia 2011-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2465/1/10_Ayub.pdf Ayub Mohd Yatim, and Norazmir Md Nor, (2011) Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati). Sains Malaysiana, 40 (2). pp. 147-154. ISSN 0126-6039 http://www.ukm.my/jsm/
spellingShingle	Ayub Mohd Yatim, Norazmir Md Nor, Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title	Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title_full	Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title_fullStr	Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title_full_unstemmed	Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title_short	Pink guava (psidium guajava) puree supplement on high fat diet-induced obese rats: effects on antioxidant enzyme activities, kidney and liver functions (supplemen puri jambu batu merah (psidium guajava) ke atas tikus teraruh obesiti: kesan terhadap aktiviti enzim antioksidan, fungsi ginjal dan fungsi hati)
title_sort	pink guava psidium guajava puree supplement on high fat diet induced obese rats effects on antioxidant enzyme activities kidney and liver functions supplemen puri jambu batu merah psidium guajava ke atas tikus teraruh obesiti kesan terhadap aktiviti enzim antioksidan fungsi ginjal dan fungsi hati
url	http://journalarticle.ukm.my/2465/1/10_Ayub.pdf
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