Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://journalarticle.ukm.my/24810/1/SMS%2017.pdf |
| _version_ | 1824449819059421184 |
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| author | Sulistyowaty, Melanny Ika Fitri, Suciati Yuliati, Ninis Amrillah, Tahta Che Azurahanim Che Abdullah, Setyawan, Dwi |
| author_facet | Sulistyowaty, Melanny Ika Fitri, Suciati Yuliati, Ninis Amrillah, Tahta Che Azurahanim Che Abdullah, Setyawan, Dwi |
| author_sort | Sulistyowaty, Melanny Ika |
| collection | UKM |
| description | Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solubility of pMCA using the cocrystal formation (cocrystallization) strategy. Here, we use caffeine as a coformer that can interact very well with pMCA via non-covalent bonding and Van der Waals interaction to achieve cocrystal formation. The cocrystal samples were successfully synthesized using various synthesis techniques; physical mixture, solvent evaporation, and microwave radiation methods. It shows that the solubility of the samples synthesized using microwave-assisted and solvent evaporation increases about 3.30 and 3.12 times, respectively, whereas the dissolution rate profile increases 2.50 and 2.39 times, respectively, compared to pure APMS. Our findings explain the importance of the cocrystal formation strategy to enhance the solubility of active material pMCA. This strategy can also be used as a standard formulation of a new drug system with excellent solubility and dissolution which is very important for the pharmaceutical industry. |
| first_indexed | 2025-02-19T02:08:53Z |
| format | Article |
| id | ukm.eprints-24810 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:08:53Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-248102025-02-05T08:08:48Z http://journalarticle.ukm.my/24810/ Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer Sulistyowaty, Melanny Ika Fitri, Suciati Yuliati, Ninis Amrillah, Tahta Che Azurahanim Che Abdullah, Setyawan, Dwi Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solubility of pMCA using the cocrystal formation (cocrystallization) strategy. Here, we use caffeine as a coformer that can interact very well with pMCA via non-covalent bonding and Van der Waals interaction to achieve cocrystal formation. The cocrystal samples were successfully synthesized using various synthesis techniques; physical mixture, solvent evaporation, and microwave radiation methods. It shows that the solubility of the samples synthesized using microwave-assisted and solvent evaporation increases about 3.30 and 3.12 times, respectively, whereas the dissolution rate profile increases 2.50 and 2.39 times, respectively, compared to pure APMS. Our findings explain the importance of the cocrystal formation strategy to enhance the solubility of active material pMCA. This strategy can also be used as a standard formulation of a new drug system with excellent solubility and dissolution which is very important for the pharmaceutical industry. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24810/1/SMS%2017.pdf Sulistyowaty, Melanny Ika and Fitri, Suciati and Yuliati, Ninis and Amrillah, Tahta and Che Azurahanim Che Abdullah, and Setyawan, Dwi (2024) Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer. Sains Malaysiana, 53 (10). pp. 3445-3454. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num10_2024/contentsVol53num10_2024.html |
| spellingShingle | Sulistyowaty, Melanny Ika Fitri, Suciati Yuliati, Ninis Amrillah, Tahta Che Azurahanim Che Abdullah, Setyawan, Dwi Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title | Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title_full | Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title_fullStr | Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title_full_unstemmed | Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title_short | Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer |
| title_sort | solubility and dissolution improvement of paramethoxycinnamic acid pmca induced by cocrystal formation using caffeine as a coformer |
| url | http://journalarticle.ukm.my/24810/1/SMS%2017.pdf |
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