Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain
The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also hi...
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| Format: | Article |
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Universiti Kebangsaan Malaysia
1996
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| author | Danial Yahya, M. Chien , C. Lung Yacob L. Pinnas, |
| author_facet | Danial Yahya, M. Chien , C. Lung Yacob L. Pinnas, |
| author_sort | Danial Yahya, M. |
| collection | UKM |
| description | The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice. |
| first_indexed | 2024-03-06T03:50:57Z |
| format | Article |
| id | ukm.eprints-3681 |
| institution | Universiti Kebangsaan Malaysia |
| last_indexed | 2024-03-06T03:50:57Z |
| publishDate | 1996 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-36812012-03-29T04:33:57Z http://journalarticle.ukm.my/3681/ Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain Danial Yahya, M. Chien , C. Lung Yacob L. Pinnas, The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice. Universiti Kebangsaan Malaysia 1996-03 Article PeerReviewed Danial Yahya, M. and Chien , C. Lung and Yacob L. Pinnas, (1996) Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain. Sains Malaysiana, 25 (1). pp. 77-86. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol25num1_1996/vol25num1_96page77-86.html |
| spellingShingle | Danial Yahya, M. Chien , C. Lung Yacob L. Pinnas, Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title | Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title_full | Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title_fullStr | Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title_full_unstemmed | Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title_short | Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain |
| title_sort | levels of malondialdehyde related immune reactants in a lupus prone mouse strain |
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