Apparent factor IX inhibitor.
The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-spec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2011
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| Online Access: | http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf |
| _version_ | 1825725523610828800 |
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| author | Jameela, S Rozika, P Rizalman, J Phan, CL Visalachy, P Chang, KM |
| author_facet | Jameela, S Rozika, P Rizalman, J Phan, CL Visalachy, P Chang, KM |
| author_sort | Jameela, S |
| collection | UKM |
| description | The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-specific inhibitor like the lupus anticoagulant which has opposite therapeutic implications. We report a patient referred to our hospital for treatment that was previously diagnosed at another medical institution as an acquired factor IX inhibitor following an investigation for a prolonged APTT. On further testing this turned out to be a potent lupus anticoagulant which interfered with the phospholipid-dependent factor assays. The use of dilution studies, chromogenic assays and phospholipid neutralization can help differentiate these inhibitors. Great care must be taken in the interpretation of factor assays in the presence of lupus anti-coagulant to avoid misdiagnosis and inappropriate treatment. |
| first_indexed | 2024-03-06T03:56:48Z |
| format | Article |
| id | ukm.eprints-5325 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T03:56:48Z |
| publishDate | 2011 |
| publisher | Penerbit UKM |
| record_format | dspace |
| spelling | ukm.eprints-53252016-12-14T06:38:06Z http://journalarticle.ukm.my/5325/ Apparent factor IX inhibitor. Jameela, S Rozika, P Rizalman, J Phan, CL Visalachy, P Chang, KM The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-specific inhibitor like the lupus anticoagulant which has opposite therapeutic implications. We report a patient referred to our hospital for treatment that was previously diagnosed at another medical institution as an acquired factor IX inhibitor following an investigation for a prolonged APTT. On further testing this turned out to be a potent lupus anticoagulant which interfered with the phospholipid-dependent factor assays. The use of dilution studies, chromogenic assays and phospholipid neutralization can help differentiate these inhibitors. Great care must be taken in the interpretation of factor assays in the presence of lupus anti-coagulant to avoid misdiagnosis and inappropriate treatment. Penerbit UKM 2011-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf Jameela, S and Rozika, P and Rizalman, J and Phan, CL and Visalachy, P and Chang, KM (2011) Apparent factor IX inhibitor. Medicine & Health, 6 (2). pp. 126-130. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal |
| spellingShingle | Jameela, S Rozika, P Rizalman, J Phan, CL Visalachy, P Chang, KM Apparent factor IX inhibitor. |
| title | Apparent factor IX inhibitor. |
| title_full | Apparent factor IX inhibitor. |
| title_fullStr | Apparent factor IX inhibitor. |
| title_full_unstemmed | Apparent factor IX inhibitor. |
| title_short | Apparent factor IX inhibitor. |
| title_sort | apparent factor ix inhibitor |
| url | http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf |
| work_keys_str_mv | AT jameelas apparentfactorixinhibitor AT rozikap apparentfactorixinhibitor AT rizalmanj apparentfactorixinhibitor AT phancl apparentfactorixinhibitor AT visalachyp apparentfactorixinhibitor AT changkm apparentfactorixinhibitor |