Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the...
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2012
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| Online Access: | http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf |
| _version_ | 1825725552382705664 |
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| author | Normah Awang, Ibrahim Baba, |
| author_facet | Normah Awang, Ibrahim Baba, |
| author_sort | Normah Awang, |
| collection | UKM |
| description | Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm-1, ν(C=S) bands in the region of 978 - 998 cm-1 and ν(Sn-S) bands in the region of 375 – 389 cm-1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C4H9)2Sn[S2CN(i-C3H7)(C6H11)]2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD50 values lower than 1.00 μg/mL. |
| first_indexed | 2024-03-06T03:57:14Z |
| format | Article |
| id | ukm.eprints-5435 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T03:57:14Z |
| publishDate | 2012 |
| publisher | Universiti Kebangsaan Malaysia |
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| spelling | ukm.eprints-54352016-12-14T06:38:26Z http://journalarticle.ukm.my/5435/ Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) Normah Awang, Ibrahim Baba, Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm-1, ν(C=S) bands in the region of 978 - 998 cm-1 and ν(Sn-S) bands in the region of 375 – 389 cm-1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C4H9)2Sn[S2CN(i-C3H7)(C6H11)]2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD50 values lower than 1.00 μg/mL. Universiti Kebangsaan Malaysia 2012-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf Normah Awang, and Ibrahim Baba, (2012) Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi). Sains Malaysiana, 41 (8). pp. 977-982. ISSN 0126-6039 http://www.ukm.my/jsm/ |
| spellingShingle | Normah Awang, Ibrahim Baba, Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title | Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities
(Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title_full | Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities
(Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title_fullStr | Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities
(Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title_full_unstemmed | Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities
(Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title_short | Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities
(Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) |
| title_sort | diorganotin iv alkylcyclohexyldithiocarbamate compounds synthesis characterization and biological activities sebatian diorganostanum iv alkilsikloheksilditiokarbamat sintesis pencirian dan aktiviti biologi |
| url | http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf |
| work_keys_str_mv | AT normahawang diorganotinivalkylcyclohexyldithiocarbamatecompoundssynthesischaracterizationandbiologicalactivitiessebatiandiorganostanumivalkilsikloheksilditiokarbamatsintesispenciriandanaktivitibiologi AT ibrahimbaba diorganotinivalkylcyclohexyldithiocarbamatecompoundssynthesischaracterizationandbiologicalactivitiessebatiandiorganostanumivalkilsikloheksilditiokarbamatsintesispenciriandanaktivitibiologi |