Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2012
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| Online Access: | http://journalarticle.ukm.my/6092/1/2011-1-17.pdf |
| _version_ | 1796930214841810944 |
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| author | Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, |
| author_facet | Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, |
| author_sort | Hui-min, Neoh |
| collection | UKM |
| description | This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects via PCR, while TPMT activity was measured using HPLC. TPMT*3C was the only mutant allele detected in 4 heterozygous carriers. These patients had significantly lower (23.0 nmol/g Hb/h) TPMT activity compared to wildtype patients (51.0 nmol/g Hb/h) (p = 0.003). Positive correlation between TPMT genotype and phenotype projects the possibility of using TPMT genotyping as a guide prior thiopurine drug administration. . |
| first_indexed | 2024-03-06T03:59:35Z |
| format | Article |
| id | ukm.eprints-6092 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T03:59:35Z |
| publishDate | 2012 |
| publisher | Penerbit UKM |
| record_format | dspace |
| spelling | ukm.eprints-60922016-12-14T06:40:21Z http://journalarticle.ukm.my/6092/ Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects via PCR, while TPMT activity was measured using HPLC. TPMT*3C was the only mutant allele detected in 4 heterozygous carriers. These patients had significantly lower (23.0 nmol/g Hb/h) TPMT activity compared to wildtype patients (51.0 nmol/g Hb/h) (p = 0.003). Positive correlation between TPMT genotype and phenotype projects the possibility of using TPMT genotyping as a guide prior thiopurine drug administration. . Penerbit UKM 2012-01-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6092/1/2011-1-17.pdf Hui-min, Neoh and Mee, Lee Looi and Muhiddin Ishak, and Mohd Ridhwan Abd Razak, and Noor Hamidah Hussin, and Zarina Latiff, and Hamidah Alias, and Rahman Jamal, (2012) Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing. Asia-Pacific Journal of Molecular Medicine, 2 ((1):1). pp. 1-3. ISSN 2232-0326 http://www.ukm.my/apjmm/ |
| spellingShingle | Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title | Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title_full | Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title_fullStr | Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title_full_unstemmed | Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title_short | Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing |
| title_sort | positive tpmt genotype phenotype correlation underscores importance of tpmt genotyping for personalized thiopurine dosing |
| url | http://journalarticle.ukm.my/6092/1/2011-1-17.pdf |
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