Xanthones from calophyllum gracilipes and their cytotoxic activity
Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2013
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| Online Access: | http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf |
| _version_ | 1796930304828506112 |
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| author | Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, |
| author_facet | Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, |
| author_sort | Nadiah Mad Nasir, |
| collection | UKM |
| description | Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ. |
| first_indexed | 2024-03-06T04:01:02Z |
| format | Article |
| id | ukm.eprints-6468 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:01:02Z |
| publishDate | 2013 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-64682016-12-14T06:41:16Z http://journalarticle.ukm.my/6468/ Xanthones from calophyllum gracilipes and their cytotoxic activity Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf Nadiah Mad Nasir, and Mawardi Rahmani, and Khozirah Shaari, and Nur Kartinee Kassim, and Go, Rusea and Stanslas, Johnson and Ethel Jeyaseela Jeyaraj, (2013) Xanthones from calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0126-6039 http://www.ukm.my/jsm/ |
| spellingShingle | Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title | Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title_full | Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title_fullStr | Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title_full_unstemmed | Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title_short | Xanthones from calophyllum gracilipes and their cytotoxic activity |
| title_sort | xanthones from calophyllum gracilipes and their cytotoxic activity |
| url | http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf |
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