A study of the utility of lactate dehydrogenase, total proteins, and adenosine deaminase in the diagnosis of pleural exudates: A new statistical approach
Background: Pleural fluid (PF) may be transudative or exudative. Total protein estimation from PF is used to detect exudative pleural effusion. Objectives: To determine the role of new suggested criteria consisting of lactate dehydrogenase (LDH), total proteins (TP), and adenosine deaminase (ADA)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/8784/1/P.286-291.pdf |
| _version_ | 1825726330885373952 |
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| author | Mihir Mehta, Simbita Marwah, Hitesh Shah, Amit Trivedi, |
| author_facet | Mihir Mehta, Simbita Marwah, Hitesh Shah, Amit Trivedi, |
| author_sort | Mihir Mehta, |
| collection | UKM |
| description | Background: Pleural fluid (PF) may be transudative or exudative. Total protein estimation from PF is used to detect
exudative pleural effusion.
Objectives: To determine the role of new suggested criteria consisting of lactate dehydrogenase (LDH), total proteins (TP),
and adenosine deaminase (ADA) in diagnosis of pleural effusion and differentiate it into transudative and exudative and
also to compare it with Light’s criteria.
Materials and Methods: This was a cross-sectional study comprising 101 patients with pleural effusion, classified by
previously established criteria as transudates or exudates. The study was carried out in a 550-bedded tertiary-care, ruralbased,
teaching hospital for 1 year. Diagnostic parameters mentioned in Light’s criteria were performed from PF and
serum, whereas parameters of the new criteria used in our study (LDH, TP, and ADA) were performed from PF. Receiveroperating
characteristic curve was used to determine the cutoffs, multiple parallel tests were applied to combine individual
test markers to optimize diagnostic accuracy and sensitivity, and specificity and diagnostic accuracy for each test were
calculated.
Results: After using multiple parallel tests, the sensitivity, specificity, and accuracy of Light’s criteria for diagnosing
exudates were 98.9%, 75%, and 95% and those for transudates were 95.29%, 80%, and 93%, respectively. Whereas for
the proposed new criteria, sensitivity, specificity, and accuracy for diagnosing exudates were 98.81%, 93.75%, and 98%
and those for transudates were 95.23%, 87.5%, and 94%, respectively. The accuracy of new criteria was comparable to
that of Light’s criteria (p = 0.0018).
Conclusion: From our study, it can be concluded that PF analysis of LDH, TP, and ADA has high sensitivity and specificity
for diagnosing pleural effusions and can be used as useful markers to suggest exudative effusions. |
| first_indexed | 2024-03-06T04:09:16Z |
| format | Article |
| id | ukm.eprints-8784 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:09:16Z |
| publishDate | 2015 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-87842016-12-14T06:48:08Z http://journalarticle.ukm.my/8784/ A study of the utility of lactate dehydrogenase, total proteins, and adenosine deaminase in the diagnosis of pleural exudates: A new statistical approach Mihir Mehta, Simbita Marwah, Hitesh Shah, Amit Trivedi, Background: Pleural fluid (PF) may be transudative or exudative. Total protein estimation from PF is used to detect exudative pleural effusion. Objectives: To determine the role of new suggested criteria consisting of lactate dehydrogenase (LDH), total proteins (TP), and adenosine deaminase (ADA) in diagnosis of pleural effusion and differentiate it into transudative and exudative and also to compare it with Light’s criteria. Materials and Methods: This was a cross-sectional study comprising 101 patients with pleural effusion, classified by previously established criteria as transudates or exudates. The study was carried out in a 550-bedded tertiary-care, ruralbased, teaching hospital for 1 year. Diagnostic parameters mentioned in Light’s criteria were performed from PF and serum, whereas parameters of the new criteria used in our study (LDH, TP, and ADA) were performed from PF. Receiveroperating characteristic curve was used to determine the cutoffs, multiple parallel tests were applied to combine individual test markers to optimize diagnostic accuracy and sensitivity, and specificity and diagnostic accuracy for each test were calculated. Results: After using multiple parallel tests, the sensitivity, specificity, and accuracy of Light’s criteria for diagnosing exudates were 98.9%, 75%, and 95% and those for transudates were 95.29%, 80%, and 93%, respectively. Whereas for the proposed new criteria, sensitivity, specificity, and accuracy for diagnosing exudates were 98.81%, 93.75%, and 98% and those for transudates were 95.23%, 87.5%, and 94%, respectively. The accuracy of new criteria was comparable to that of Light’s criteria (p = 0.0018). Conclusion: From our study, it can be concluded that PF analysis of LDH, TP, and ADA has high sensitivity and specificity for diagnosing pleural effusions and can be used as useful markers to suggest exudative effusions. Universiti Kebangsaan Malaysia 2015-06-17 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8784/1/P.286-291.pdf Mihir Mehta, and Simbita Marwah, and Hitesh Shah, and Amit Trivedi, (2015) A study of the utility of lactate dehydrogenase, total proteins, and adenosine deaminase in the diagnosis of pleural exudates: A new statistical approach. International Journal of Public Health Research, 4 (2). pp. 286-291. ISSN 2232-0245 www.ijphr.ukm.my |
| spellingShingle | Mihir Mehta, Simbita Marwah, Hitesh Shah, Amit Trivedi, A study of the utility of lactate dehydrogenase, total proteins, and adenosine deaminase in the diagnosis of pleural exudates: A new statistical approach |
| title | A study of the utility of lactate dehydrogenase,
total proteins, and adenosine deaminase in the diagnosis
of pleural exudates: A new statistical approach |
| title_full | A study of the utility of lactate dehydrogenase,
total proteins, and adenosine deaminase in the diagnosis
of pleural exudates: A new statistical approach |
| title_fullStr | A study of the utility of lactate dehydrogenase,
total proteins, and adenosine deaminase in the diagnosis
of pleural exudates: A new statistical approach |
| title_full_unstemmed | A study of the utility of lactate dehydrogenase,
total proteins, and adenosine deaminase in the diagnosis
of pleural exudates: A new statistical approach |
| title_short | A study of the utility of lactate dehydrogenase,
total proteins, and adenosine deaminase in the diagnosis
of pleural exudates: A new statistical approach |
| title_sort | study of the utility of lactate dehydrogenase total proteins and adenosine deaminase in the diagnosis of pleural exudates a new statistical approach |
| url | http://journalarticle.ukm.my/8784/1/P.286-291.pdf |
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