The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro
Aqueous, acid hydrolysed and ethanolic extracts of the roots and leaves of Labisia pumila var. alata and Labisia pumila var. alata and Labisia pumila var. pumila were investigated for their oestrogenic and cytotoxic effects using Ishikawa cell line by performing an in vitro Ishikawa alkaline phospha...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2003
|
| Online Access: | http://journalarticle.ukm.my/950/1/jurnal6.pdf |
| _version_ | 1796914325340815360 |
|---|---|
| author | Jamia A.Jamal, Houghton P.J, Milligan S.R, Ibrahim Jantan, |
| author_facet | Jamia A.Jamal, Houghton P.J, Milligan S.R, Ibrahim Jantan, |
| author_sort | Jamia A.Jamal, |
| collection | UKM |
| description | Aqueous, acid hydrolysed and ethanolic extracts of the roots and leaves of Labisia pumila var. alata and Labisia pumila var. alata and Labisia pumila var. pumila were investigated for their oestrogenic and cytotoxic effects using Ishikawa cell line by performing an in vitro Ishikawa alkaline phosphatase assay and an in vitro protein assay, respectively. Among them, only the ethanol extract of the root of L. pumila var. alata exhibited a weak oestrogenic activity at 10-50 mg/ml. The samples that exhibited significant cytotoxic effect were the ethanol extract of the roots of L. pumila var. alata (IC50 433 mg/ml), and the aqueous extracts of the roots of L. pumila var. alata (IC50 433 mg/ml) and the leaves of L. pumila var. pumila (IC50 458 mg/ml). |
| first_indexed | 2024-03-06T03:40:56Z |
| format | Article |
| id | ukm.eprints-950 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T03:40:56Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | ukm.eprints-9502016-12-14T06:28:23Z http://journalarticle.ukm.my/950/ The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro Jamia A.Jamal, Houghton P.J, Milligan S.R, Ibrahim Jantan, Aqueous, acid hydrolysed and ethanolic extracts of the roots and leaves of Labisia pumila var. alata and Labisia pumila var. alata and Labisia pumila var. pumila were investigated for their oestrogenic and cytotoxic effects using Ishikawa cell line by performing an in vitro Ishikawa alkaline phosphatase assay and an in vitro protein assay, respectively. Among them, only the ethanol extract of the root of L. pumila var. alata exhibited a weak oestrogenic activity at 10-50 mg/ml. The samples that exhibited significant cytotoxic effect were the ethanol extract of the roots of L. pumila var. alata (IC50 433 mg/ml), and the aqueous extracts of the roots of L. pumila var. alata (IC50 433 mg/ml) and the leaves of L. pumila var. pumila (IC50 458 mg/ml). 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/950/1/jurnal6.pdf Jamia A.Jamal, and Houghton P.J, and Milligan S.R, and Ibrahim Jantan, (2003) The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro. pp. 53-60. ISSN 1675-8161 |
| spellingShingle | Jamia A.Jamal, Houghton P.J, Milligan S.R, Ibrahim Jantan, The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title | The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title_full | The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title_fullStr | The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title_full_unstemmed | The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title_short | The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro |
| title_sort | oestrogenis and cytotoxic effects of the extracts of labisia pumila var alata and labisia pumila var pumila in vitro |
| url | http://journalarticle.ukm.my/950/1/jurnal6.pdf |
| work_keys_str_mv | AT jamiaajamal theoestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT houghtonpj theoestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT milligansr theoestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT ibrahimjantan theoestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT jamiaajamal oestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT houghtonpj oestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT milligansr oestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro AT ibrahimjantan oestrogenisandcytotoxiceffectsoftheextractsoflabisiapumilavaralataandlabisiapumilavarpumilainvitro |