Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2016
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| Online Access: | http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf |
| _version_ | 1796931033435734016 |
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| author | Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, |
| author_facet | Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, |
| author_sort | Satirah Zainalabidin, |
| collection | UKM |
| description | Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle
has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies
have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead
to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure,
serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total
of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal
saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w
HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed
that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE
increased the high-density lipoprotein (HDL) concentration significantly (p<0.05) in rats given with nicotine, without
any significant changes in total cholesterol, triglyceride and low-density ipoprotein (LDL) concentration. Besides, HSE
treatment was also found to reverse malondialdehyde (MDA) level, superoxide dimustase (SOD) enzyme activity and protein
concentration significantly (p<0.05) in nicotine-treated rats. In summary, these results indicated that HSE is an effective
antioxidant against oxidative damage in heart caused by nicotine, but not as antihyperlipidemic and antihypertensive
agent in this rat model. |
| first_indexed | 2024-03-06T04:12:09Z |
| format | Article |
| id | ukm.eprints-9674 |
| institution | Universiti Kebangsaan Malaysia |
| language | English |
| last_indexed | 2024-03-06T04:12:09Z |
| publishDate | 2016 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ukm.eprints-96742016-12-14T06:50:31Z http://journalarticle.ukm.my/9674/ Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure, serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE increased the high-density lipoprotein (HDL) concentration significantly (p<0.05) in rats given with nicotine, without any significant changes in total cholesterol, triglyceride and low-density ipoprotein (LDL) concentration. Besides, HSE treatment was also found to reverse malondialdehyde (MDA) level, superoxide dimustase (SOD) enzyme activity and protein concentration significantly (p<0.05) in nicotine-treated rats. In summary, these results indicated that HSE is an effective antioxidant against oxidative damage in heart caused by nicotine, but not as antihyperlipidemic and antihypertensive agent in this rat model. Universiti Kebangsaan Malaysia 2016-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf Satirah Zainalabidin, and Siti Nor Farhanah Sh Nor Shahidin, and Siti Balkis Budin, (2016) Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats. Sains Malaysiana, 45 (2). pp. 207-214. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html |
| spellingShingle | Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats |
| title | Hibiscus sabdariffa Linn. (Roselle) protects against
nicotine-induced heart damage in rats |
| title_full | Hibiscus sabdariffa Linn. (Roselle) protects against
nicotine-induced heart damage in rats |
| title_fullStr | Hibiscus sabdariffa Linn. (Roselle) protects against
nicotine-induced heart damage in rats |
| title_full_unstemmed | Hibiscus sabdariffa Linn. (Roselle) protects against
nicotine-induced heart damage in rats |
| title_short | Hibiscus sabdariffa Linn. (Roselle) protects against
nicotine-induced heart damage in rats |
| title_sort | hibiscus sabdariffa linn roselle protects against nicotine induced heart damage in rats |
| url | http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf |
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