Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)
A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids...
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| Format: | Article |
| Language: | English |
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Elsevier
2012
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| Online Access: | http://eprints.um.edu.my/10001/1/1Triterpenes_and_steroids_from_the_leaves_of_Aglaia_exima_%28Meliaceae%29.pdf |
| _version_ | 1796946001684070400 |
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| author | Leong, K.H. |
| author_facet | Leong, K.H. |
| author_sort | Leong, K.H. |
| collection | UM |
| description | A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM). |
| first_indexed | 2024-03-06T05:25:04Z |
| format | Article |
| id | um.eprints-10001 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:25:04Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-100012018-07-31T04:26:09Z http://eprints.um.edu.my/10001/ Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) Leong, K.H. Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM). Elsevier 2012-12-15 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10001/1/1Triterpenes_and_steroids_from_the_leaves_of_Aglaia_exima_%28Meliaceae%29.pdf Leong, K.H. (2012) Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae). Fitoterapia, 83 (8). pp. 1391-1395. DOI https://doi.org/10.1016/j.fitote.2012.10.004 <https://doi.org/10.1016/j.fitote.2012.10.004>. http://www.sciencedirect.com/science/article/pii/S0367326X12002808 10.1016/j.fitote.2012.10.004 |
| spellingShingle | Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Leong, K.H. Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title_full | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title_fullStr | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title_full_unstemmed | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title_short | Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
| title_sort | triterpenes and steroids from the leaves of aglaia exima meliaceae |
| topic | Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine |
| url | http://eprints.um.edu.my/10001/1/1Triterpenes_and_steroids_from_the_leaves_of_Aglaia_exima_%28Meliaceae%29.pdf |
| work_keys_str_mv | AT leongkh triterpenesandsteroidsfromtheleavesofaglaiaeximameliaceae |