Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...
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| Format: | Article |
| Language: | English |
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Springer Verlag (Germany)
2012
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| Online Access: | http://eprints.um.edu.my/10005/1/Cytotoxic_and_antioxidant_compounds_from_the_stem_bark_of_Goniothalamus_tapisoides_Mat_Salleh.pdf |
| _version_ | 1796946002279661568 |
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| author | Leong, K.H. |
| author_facet | Leong, K.H. |
| author_sort | Leong, K.H. |
| collection | UM |
| description | Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. |
| first_indexed | 2024-03-06T05:25:04Z |
| format | Article |
| id | um.eprints-10005 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:25:04Z |
| publishDate | 2012 |
| publisher | Springer Verlag (Germany) |
| record_format | dspace |
| spelling | um.eprints-100052018-07-31T04:25:42Z http://eprints.um.edu.my/10005/ Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh Leong, K.H. Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. Springer Verlag (Germany) 2012-12-21 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10005/1/Cytotoxic_and_antioxidant_compounds_from_the_stem_bark_of_Goniothalamus_tapisoides_Mat_Salleh.pdf Leong, K.H. (2012) Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh. Molecules Online, 18 (1). pp. 128-139. DOI https://doi.org/10.3390/molecules18010128 <https://doi.org/10.3390/molecules18010128>. http://www.mdpi.com/1420-3049/18/1/128 10.3390/molecules18010128 |
| spellingShingle | Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Leong, K.H. Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title | Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title_full | Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title_fullStr | Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title_full_unstemmed | Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title_short | Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh |
| title_sort | cytotoxic and antioxidant compoundsfrom the stem bark of goniothalamus tapisoides mat salleh |
| topic | Q Science (General) QD Chemistry QH301 Biology QK Botany R Medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine |
| url | http://eprints.um.edu.my/10005/1/Cytotoxic_and_antioxidant_compounds_from_the_stem_bark_of_Goniothalamus_tapisoides_Mat_Salleh.pdf |
| work_keys_str_mv | AT leongkh cytotoxicandantioxidantcompoundsfromthestembarkofgoniothalamustapisoidesmatsalleh |