Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial
Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10195/1/Efficacy_of_microbial_cell_preparation_in_improving_chronic.pdf |
| _version_ | 1825719821725073408 |
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| author | Chin, K.F. Jayasimhan, S. Yap, N.Y. Roest, Y. Rajandram, R. |
| author_facet | Chin, K.F. Jayasimhan, S. Yap, N.Y. Roest, Y. Rajandram, R. |
| author_sort | Chin, K.F. |
| collection | UM |
| description | Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of chronic constipation.
Methods: A total of 120 constipated adults diagnosed using Rome III criteria were randomized and given
either microbial cell preparation or placebo to be consumed twice daily. Follow-up was done after a 7-day intervention based on a questionnaire which includes an assessment of symptom profile and a stool diary.
Results: During the intervention period, the stool frequency was higher (p = 0.001) in the treatment group. Subjects experienced less straining (p = 0.001) and sensation of incomplete evacuation (p < 0.001), as well as improved stool consistency (p < 0.001) compared to the placebo group. While a higher proportion of subjects in the treatment group had a reduction in anorectal blockage sensation and having to defecate by manual maneuvers, the differences were not statistically significant. |
| first_indexed | 2024-03-06T05:25:37Z |
| format | Article |
| id | um.eprints-10195 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:25:37Z |
| publishDate | 2013 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-101952014-10-23T08:34:13Z http://eprints.um.edu.my/10195/ Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial Chin, K.F. Jayasimhan, S. Yap, N.Y. Roest, Y. Rajandram, R. R Medicine (General) Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of chronic constipation. Methods: A total of 120 constipated adults diagnosed using Rome III criteria were randomized and given either microbial cell preparation or placebo to be consumed twice daily. Follow-up was done after a 7-day intervention based on a questionnaire which includes an assessment of symptom profile and a stool diary. Results: During the intervention period, the stool frequency was higher (p = 0.001) in the treatment group. Subjects experienced less straining (p = 0.001) and sensation of incomplete evacuation (p < 0.001), as well as improved stool consistency (p < 0.001) compared to the placebo group. While a higher proportion of subjects in the treatment group had a reduction in anorectal blockage sensation and having to defecate by manual maneuvers, the differences were not statistically significant. Elsevier 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10195/1/Efficacy_of_microbial_cell_preparation_in_improving_chronic.pdf Chin, K.F. and Jayasimhan, S. and Yap, N.Y. and Roest, Y. and Rajandram, R. (2013) Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 32. pp. 928-934. ISSN 0261-5614, |
| spellingShingle | R Medicine (General) Chin, K.F. Jayasimhan, S. Yap, N.Y. Roest, Y. Rajandram, R. Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial |
| title | Efficacy of microbial cell preparation in improving chronic
constipation: a randomized, double-blind, placebo-controlled trial |
| title_full | Efficacy of microbial cell preparation in improving chronic
constipation: a randomized, double-blind, placebo-controlled trial |
| title_fullStr | Efficacy of microbial cell preparation in improving chronic
constipation: a randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Efficacy of microbial cell preparation in improving chronic
constipation: a randomized, double-blind, placebo-controlled trial |
| title_short | Efficacy of microbial cell preparation in improving chronic
constipation: a randomized, double-blind, placebo-controlled trial |
| title_sort | efficacy of microbial cell preparation in improving chronic constipation a randomized double blind placebo controlled trial |
| topic | R Medicine (General) |
| url | http://eprints.um.edu.my/10195/1/Efficacy_of_microbial_cell_preparation_in_improving_chronic.pdf |
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