Sialic acid and vascular cell adhesion molecule-l as early markers in the first degree relatives of type 2 diabetes mellitus patients
Levels of sialic acid and Vascular Cell Adhesion Molecule-I (VCAM-I)in the first degree relatives of type 2 diabetes mellitus patients and their possible role as an early marker of the prediabetic stage were studied in 74 controls and 150 first degree relatives. The total sialic acid concentration w...
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| Format: | Article |
| Language: | English |
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Asian Network for Scientific Information (ANSINET)
2006
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| Online Access: | http://eprints.um.edu.my/10284/1/Sialic_Acid_and_Vascular_Cell_Adhesion_Molecule-l_as_Early.pdf |
| _version_ | 1796946050141913088 |
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| author | Ismail, I.S. Qvist, R. Muniandy, S. Hew, F.L. Vellasamy, K.M. Chinna, K. Zaini, A. |
| author_facet | Ismail, I.S. Qvist, R. Muniandy, S. Hew, F.L. Vellasamy, K.M. Chinna, K. Zaini, A. |
| author_sort | Ismail, I.S. |
| collection | UM |
| description | Levels of sialic acid and Vascular Cell Adhesion Molecule-I (VCAM-I)in the first degree relatives of type 2 diabetes mellitus patients and their possible role as an early marker of the prediabetic stage were studied in 74 controls and 150 first degree relatives. The total sialic acid concentration was significantly higher (p<O.05) in the first degree relatives compared to the control subjects. Amongst the offsprings, the total sialic acid concentration was significantly higher in the offspring with Normal Glucose Tolerance (NGT) than those with Impaired Glucose
Tolerance (IGT). However the level of VCAM-I did not differ amongst the controls and the first degree relatives. The total cholesterol and triglycerides were significantly higher (p<0.05) in the offspring with IGT when compared to the control subjects and the offspring with NGT. The above data suggests that desialylation of the vascular endothelium is an early event that precedes the expression of IGT or any lipid changes in asymptomatic offspring of one type 2 diabetic parent. |
| first_indexed | 2024-03-06T05:25:47Z |
| format | Article |
| id | um.eprints-10284 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:25:47Z |
| publishDate | 2006 |
| publisher | Asian Network for Scientific Information (ANSINET) |
| record_format | dspace |
| spelling | um.eprints-102842014-10-29T00:55:22Z http://eprints.um.edu.my/10284/ Sialic acid and vascular cell adhesion molecule-l as early markers in the first degree relatives of type 2 diabetes mellitus patients Ismail, I.S. Qvist, R. Muniandy, S. Hew, F.L. Vellasamy, K.M. Chinna, K. Zaini, A. R Medicine (General) Levels of sialic acid and Vascular Cell Adhesion Molecule-I (VCAM-I)in the first degree relatives of type 2 diabetes mellitus patients and their possible role as an early marker of the prediabetic stage were studied in 74 controls and 150 first degree relatives. The total sialic acid concentration was significantly higher (p<O.05) in the first degree relatives compared to the control subjects. Amongst the offsprings, the total sialic acid concentration was significantly higher in the offspring with Normal Glucose Tolerance (NGT) than those with Impaired Glucose Tolerance (IGT). However the level of VCAM-I did not differ amongst the controls and the first degree relatives. The total cholesterol and triglycerides were significantly higher (p<0.05) in the offspring with IGT when compared to the control subjects and the offspring with NGT. The above data suggests that desialylation of the vascular endothelium is an early event that precedes the expression of IGT or any lipid changes in asymptomatic offspring of one type 2 diabetic parent. Asian Network for Scientific Information (ANSINET) 2006 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10284/1/Sialic_Acid_and_Vascular_Cell_Adhesion_Molecule-l_as_Early.pdf Ismail, I.S. and Qvist, R. and Muniandy, S. and Hew, F.L. and Vellasamy, K.M. and Chinna, K. and Zaini, A. (2006) Sialic acid and vascular cell adhesion molecule-l as early markers in the first degree relatives of type 2 diabetes mellitus patients. Journal of Medical Sciences, 6 (2). pp. 235-240. ISSN 1682-4474, |
| spellingShingle | R Medicine (General) Ismail, I.S. Qvist, R. Muniandy, S. Hew, F.L. Vellasamy, K.M. Chinna, K. Zaini, A. Sialic acid and vascular cell adhesion molecule-l as early markers in the first degree relatives of type 2 diabetes mellitus patients |
| title | Sialic acid and vascular cell adhesion molecule-l as early
markers in the first degree relatives of type 2 diabetes mellitus patients |
| title_full | Sialic acid and vascular cell adhesion molecule-l as early
markers in the first degree relatives of type 2 diabetes mellitus patients |
| title_fullStr | Sialic acid and vascular cell adhesion molecule-l as early
markers in the first degree relatives of type 2 diabetes mellitus patients |
| title_full_unstemmed | Sialic acid and vascular cell adhesion molecule-l as early
markers in the first degree relatives of type 2 diabetes mellitus patients |
| title_short | Sialic acid and vascular cell adhesion molecule-l as early
markers in the first degree relatives of type 2 diabetes mellitus patients |
| title_sort | sialic acid and vascular cell adhesion molecule l as early markers in the first degree relatives of type 2 diabetes mellitus patients |
| topic | R Medicine (General) |
| url | http://eprints.um.edu.my/10284/1/Sialic_Acid_and_Vascular_Cell_Adhesion_Molecule-l_as_Early.pdf |
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