Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydro...
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| Format: | Article |
| Language: | English |
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Elsevier
2012
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| Online Access: | http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf |
| _version_ | 1825719835363901440 |
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| author | Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul |
| author_facet | Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul |
| author_sort | Tan, Hooi Poay |
| collection | UM |
| description | The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases. |
| first_indexed | 2024-03-06T05:25:49Z |
| format | Article |
| id | um.eprints-10294 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:25:49Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-102942019-12-03T03:34:11Z http://eprints.um.edu.my/10294/ Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul QD Chemistry QH Natural history The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf Tan, Hooi Poay and Wong, Daniel Zin Hua and Ling, Sui Kiong and Chuah, Cheng Hock and Kadir, Habsah Abdul (2012) Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia. Fitoterapia, 83 (1). pp. 223-229. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2011.10.019 <https://doi.org/10.1016/j.fitote.2011.10.019>. https://doi.org/10.1016/j.fitote.2011.10.019 doi:10.1016/j.fitote.2011.10.019 |
| spellingShingle | QD Chemistry QH Natural history Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title | Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title_full | Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title_fullStr | Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title_full_unstemmed | Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title_short | Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| title_sort | neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of phyllagathis rotundifolia |
| topic | QD Chemistry QH Natural history |
| url | http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf |
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