Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species
Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreo...
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| Format: | Article |
| Language: | English |
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Elsevier
2012
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| Online Access: | http://eprints.um.edu.my/10453/1/Anti-acetylcholinesterase%2C_anti-%CE%B1-glucosidase%2C_anti-leishmanial_and_anti-fungal_activities_of_chemical_constituents_of_Beilschmiedia_species.pdf |
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| author | Awang, Khalijah Mollataghi, A. Coudiere, E. Hadi, A.H.A. Mukhtar, M.R. Litaudon, M. Ata, A. |
| author_facet | Awang, Khalijah Mollataghi, A. Coudiere, E. Hadi, A.H.A. Mukhtar, M.R. Litaudon, M. Ata, A. |
| author_sort | Awang, Khalijah |
| collection | UM |
| description | Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid,N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE),
anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays. |
| first_indexed | 2024-03-06T05:26:11Z |
| format | Article |
| id | um.eprints-10453 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:11Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-104532019-03-08T08:34:37Z http://eprints.um.edu.my/10453/ Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species Awang, Khalijah Mollataghi, A. Coudiere, E. Hadi, A.H.A. Mukhtar, M.R. Litaudon, M. Ata, A. QD Chemistry Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid,N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10453/1/Anti-acetylcholinesterase%2C_anti-%CE%B1-glucosidase%2C_anti-leishmanial_and_anti-fungal_activities_of_chemical_constituents_of_Beilschmiedia_species.pdf Awang, Khalijah and Mollataghi, A. and Coudiere, E. and Hadi, A.H.A. and Mukhtar, M.R. and Litaudon, M. and Ata, A. (2012) Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. Fitoterapia, 83. pp. 298-302. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2011.11.009 <https://doi.org/10.1016/j.fitote.2011.11.009>. doi: 10.1016/j.fitote.2011.11.009 |
| spellingShingle | QD Chemistry Awang, Khalijah Mollataghi, A. Coudiere, E. Hadi, A.H.A. Mukhtar, M.R. Litaudon, M. Ata, A. Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title | Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title_full | Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title_fullStr | Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title_full_unstemmed | Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title_short | Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species |
| title_sort | anti acetylcholinesterase anti α glucosidase anti leishmanial and anti fungal activities of chemical constituents of beilschmiedia species |
| topic | QD Chemistry |
| url | http://eprints.um.edu.my/10453/1/Anti-acetylcholinesterase%2C_anti-%CE%B1-glucosidase%2C_anti-leishmanial_and_anti-fungal_activities_of_chemical_constituents_of_Beilschmiedia_species.pdf |
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