Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes
We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10470/1/Effects_of_ambient_glycaemic_state_on_growth_hormone.pdf |
| _version_ | 1825719864228052992 |
|---|---|
| author | Ismail, I.S. Scanlon, M.F. Peters, J.R. |
| author_facet | Ismail, I.S. Scanlon, M.F. Peters, J.R. |
| author_sort | Ismail, I.S. |
| collection | UM |
| description | We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with no evidence of complications were recruited. There was no significant difference between
basal GH levels during euglycaemia and hyperglycaemia
(5.50 vs 5.53 mU/l). Nor was there a significant difference
when mean \ GH levels (33.9 vs 27.4 mU/l) or mean area
under GH curve (2331 vs 4038 mU min/l) during euglycaemia
or hyperglycaemia were compared. We find no evidence therefore to support short-term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of shortterm changes in glycaemic control on hypothalamic release of somatostatin in the aetiology of GH hypersecretion in insulin-dependent diabetes mellitus. |
| first_indexed | 2024-03-06T05:26:14Z |
| format | Article |
| id | um.eprints-10470 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:14Z |
| publishDate | 1991 |
| publisher | Wiley |
| record_format | dspace |
| spelling | um.eprints-104702014-11-10T01:50:06Z http://eprints.um.edu.my/10470/ Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes Ismail, I.S. Scanlon, M.F. Peters, J.R. R Medicine (General) We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with no evidence of complications were recruited. There was no significant difference between basal GH levels during euglycaemia and hyperglycaemia (5.50 vs 5.53 mU/l). Nor was there a significant difference when mean \ GH levels (33.9 vs 27.4 mU/l) or mean area under GH curve (2331 vs 4038 mU min/l) during euglycaemia or hyperglycaemia were compared. We find no evidence therefore to support short-term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of shortterm changes in glycaemic control on hypothalamic release of somatostatin in the aetiology of GH hypersecretion in insulin-dependent diabetes mellitus. Wiley 1991 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10470/1/Effects_of_ambient_glycaemic_state_on_growth_hormone.pdf Ismail, I.S. and Scanlon, M.F. and Peters, J.R. (1991) Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes. Clinical Endocrinology, 35. pp. 499-504. ISSN 0300-0664, |
| spellingShingle | R Medicine (General) Ismail, I.S. Scanlon, M.F. Peters, J.R. Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes |
| title | Effects of ambient glycaemic state on growth hormone
responsiveness in insulin-dependent diabetes |
| title_full | Effects of ambient glycaemic state on growth hormone
responsiveness in insulin-dependent diabetes |
| title_fullStr | Effects of ambient glycaemic state on growth hormone
responsiveness in insulin-dependent diabetes |
| title_full_unstemmed | Effects of ambient glycaemic state on growth hormone
responsiveness in insulin-dependent diabetes |
| title_short | Effects of ambient glycaemic state on growth hormone
responsiveness in insulin-dependent diabetes |
| title_sort | effects of ambient glycaemic state on growth hormone responsiveness in insulin dependent diabetes |
| topic | R Medicine (General) |
| url | http://eprints.um.edu.my/10470/1/Effects_of_ambient_glycaemic_state_on_growth_hormone.pdf |
| work_keys_str_mv | AT ismailis effectsofambientglycaemicstateongrowthhormoneresponsivenessininsulindependentdiabetes AT scanlonmf effectsofambientglycaemicstateongrowthhormoneresponsivenessininsulindependentdiabetes AT petersjr effectsofambientglycaemicstateongrowthhormoneresponsivenessininsulindependentdiabetes |