Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery
Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracte...
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| Format: | Article |
| Language: | English |
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Springer Verlag
2012
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| Online Access: | http://eprints.um.edu.my/10486/1/Vasorelaxant_effect_of_isoquinoline_derivatives_from_two_species_of_Popowia_perakensis_and_Phaeanthus_crassipetalus_on_rat_aortic_artery.pdf |
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| author | Awang, K. Zaima, K. Takeyama, Y. Koga, I. Saito, A. Tamamoto, H. Syed Abd. Azziz, S.S. Mukhtar, M.R. Hadi, A.H. Morita, H. |
| author_facet | Awang, K. Zaima, K. Takeyama, Y. Koga, I. Saito, A. Tamamoto, H. Syed Abd. Azziz, S.S. Mukhtar, M.R. Hadi, A.H. Morita, H. |
| author_sort | Awang, K. |
| collection | UM |
| description | Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 μM), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 μM. The action of (-)-limacine (4) was deduced to be mediated through the increased release of NO from endothelial cells, and that of pecrassipine A (7) and backebergine (12) partly mediated by NO release. Further, the action of pecrassipine A (7) and backebergine (12) may be attributed to their inhibition of the voltage-dependent Ca(2+) channel and receptor-operated Ca(2+) channel. |
| first_indexed | 2024-03-06T05:26:16Z |
| format | Article |
| id | um.eprints-10486 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:16Z |
| publishDate | 2012 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | um.eprints-104862014-11-11T04:19:29Z http://eprints.um.edu.my/10486/ Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery Awang, K. Zaima, K. Takeyama, Y. Koga, I. Saito, A. Tamamoto, H. Syed Abd. Azziz, S.S. Mukhtar, M.R. Hadi, A.H. Morita, H. QD Chemistry Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 μM), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 μM. The action of (-)-limacine (4) was deduced to be mediated through the increased release of NO from endothelial cells, and that of pecrassipine A (7) and backebergine (12) partly mediated by NO release. Further, the action of pecrassipine A (7) and backebergine (12) may be attributed to their inhibition of the voltage-dependent Ca(2+) channel and receptor-operated Ca(2+) channel. Springer Verlag 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10486/1/Vasorelaxant_effect_of_isoquinoline_derivatives_from_two_species_of_Popowia_perakensis_and_Phaeanthus_crassipetalus_on_rat_aortic_artery.pdf Awang, K. and Zaima, K. and Takeyama, Y. and Koga, I. and Saito, A. and Tamamoto, H. and Syed Abd. Azziz, S.S. and Mukhtar, M.R. and Hadi, A.H. and Morita, H. (2012) Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery. Journal of Natural Medicines, 66. pp. 421-427. ISSN 1340-3443, |
| spellingShingle | QD Chemistry Awang, K. Zaima, K. Takeyama, Y. Koga, I. Saito, A. Tamamoto, H. Syed Abd. Azziz, S.S. Mukhtar, M.R. Hadi, A.H. Morita, H. Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title | Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title_full | Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title_fullStr | Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title_full_unstemmed | Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title_short | Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery |
| title_sort | vasorelaxant effect of isoquinoline derivatives from two species of popowia perakensis and phaeanthus crassipetalus on rat aortic artery |
| topic | QD Chemistry |
| url | http://eprints.um.edu.my/10486/1/Vasorelaxant_effect_of_isoquinoline_derivatives_from_two_species_of_Popowia_perakensis_and_Phaeanthus_crassipetalus_on_rat_aortic_artery.pdf |
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