Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were el...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012
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| Online Access: | http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf |
| _version_ | 1825719868123512832 |
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| author | Awang, Khalijah Harneti, D. Tjokronegoro, R. Safari, A. Supratman, U. Loong, X.M. Mukhtar, M.R. Mohamad, K. Hayashi, H. |
| author_facet | Awang, Khalijah Harneti, D. Tjokronegoro, R. Safari, A. Supratman, U. Loong, X.M. Mukhtar, M.R. Mohamad, K. Hayashi, H. |
| author_sort | Awang, Khalijah |
| collection | UM |
| description | Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 μg/mL, respectively. |
| first_indexed | 2024-03-06T05:26:17Z |
| format | Article |
| id | um.eprints-10494 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:17Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-104942019-03-08T08:36:39Z http://eprints.um.edu.my/10494/ Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) Awang, Khalijah Harneti, D. Tjokronegoro, R. Safari, A. Supratman, U. Loong, X.M. Mukhtar, M.R. Mohamad, K. Hayashi, H. QD Chemistry Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 μg/mL, respectively. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf Awang, Khalijah and Harneti, D. and Tjokronegoro, R. and Safari, A. and Supratman, U. and Loong, X.M. and Mukhtar, M.R. and Mohamad, K. and Hayashi, H. (2012) Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae). Phytochemistry Letters, 5 (3). pp. 496-499. ISSN 1874-3900, |
| spellingShingle | QD Chemistry Awang, Khalijah Harneti, D. Tjokronegoro, R. Safari, A. Supratman, U. Loong, X.M. Mukhtar, M.R. Mohamad, K. Hayashi, H. Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title | Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title_full | Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title_fullStr | Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title_full_unstemmed | Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title_short | Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) |
| title_sort | cytotoxic triterpenoids from the bark of aglaia smithii meliaceae |
| topic | QD Chemistry |
| url | http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf |
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