Gynura procumbens causes vasodilation by inhibiting angiotensin II and enhancing bradykinin actions
Previous studies showed that Gynura procumbens reduced blood pressure by blocking calcium channels and inhibiting the angiotensin-converting enzyme activity. The present experiments were to further explore the effects and mechanisms of a purer aqueous fraction (FA-I) of G. procumbens on angiotensin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Lippincott, Williams & Wilkins
2013
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| Online Access: | http://eprints.um.edu.my/10502/1/Gynura_procumbens_Causes_Vasodilation_by_Inhibiting.pdf |
| _version_ | 1796946084127309824 |
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| author | Lam, S.K. Poh, T.F. Ng, H.K. Hoe, S.Z. |
| author_facet | Lam, S.K. Poh, T.F. Ng, H.K. Hoe, S.Z. |
| author_sort | Lam, S.K. |
| collection | UM |
| description | Previous studies showed that Gynura procumbens reduced blood pressure by blocking calcium channels and inhibiting the angiotensin-converting enzyme activity. The present experiments were to further explore the effects and mechanisms of a purer aqueous fraction (FA-I) of G. procumbens on angiotensin I (Ang I)–induced and angiotensin
II (Ang II)–induced contraction of aortic rings and also on the bradykinin (BK) effect on cardiovascular system. Rat aortic rings suspended in organ chambers were used to investigate the vascular reactivity of FA-I. Effect of FA-I on BK was studied by in vitro and in vivo methods. Results show that FA-I significantly (P < 0.05) decreased the contraction evoked by Ang I and Ang II. In the presence
of indomethacin (10 µM) or N-nitro-L-arginine methyl ester (0.1 µM), the inhibitory effect of FA-I on Ang II–induced contraction of aortic rings was reduced. Besides, FA-I potentiated the vasorelaxant effect and enhanced the blood pressure–lowering effect of BK. In conclusion, FA-I reduced the contraction evoked by Ang II probably via the endothelium-dependent pathways, which involve activation of
the release of nitric oxide and prostaglandins. The inhibition of angiotensin-converting enzyme activity by FA-I may contribute to the potentiation of the effects of BK on cardiovascular system. |
| first_indexed | 2024-03-06T05:26:18Z |
| format | Article |
| id | um.eprints-10502 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:18Z |
| publishDate | 2013 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | um.eprints-105022014-10-13T01:37:17Z http://eprints.um.edu.my/10502/ Gynura procumbens causes vasodilation by inhibiting angiotensin II and enhancing bradykinin actions Lam, S.K. Poh, T.F. Ng, H.K. Hoe, S.Z. R Medicine (General) Previous studies showed that Gynura procumbens reduced blood pressure by blocking calcium channels and inhibiting the angiotensin-converting enzyme activity. The present experiments were to further explore the effects and mechanisms of a purer aqueous fraction (FA-I) of G. procumbens on angiotensin I (Ang I)–induced and angiotensin II (Ang II)–induced contraction of aortic rings and also on the bradykinin (BK) effect on cardiovascular system. Rat aortic rings suspended in organ chambers were used to investigate the vascular reactivity of FA-I. Effect of FA-I on BK was studied by in vitro and in vivo methods. Results show that FA-I significantly (P < 0.05) decreased the contraction evoked by Ang I and Ang II. In the presence of indomethacin (10 µM) or N-nitro-L-arginine methyl ester (0.1 µM), the inhibitory effect of FA-I on Ang II–induced contraction of aortic rings was reduced. Besides, FA-I potentiated the vasorelaxant effect and enhanced the blood pressure–lowering effect of BK. In conclusion, FA-I reduced the contraction evoked by Ang II probably via the endothelium-dependent pathways, which involve activation of the release of nitric oxide and prostaglandins. The inhibition of angiotensin-converting enzyme activity by FA-I may contribute to the potentiation of the effects of BK on cardiovascular system. Lippincott, Williams & Wilkins 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10502/1/Gynura_procumbens_Causes_Vasodilation_by_Inhibiting.pdf Lam, S.K. and Poh, T.F. and Ng, H.K. and Hoe, S.Z. (2013) Gynura procumbens causes vasodilation by inhibiting angiotensin II and enhancing bradykinin actions. Journal of Cardiovascular Pharmacology and Therapeutics, 61 (5). pp. 378-384. ISSN 0160-2446, |
| spellingShingle | R Medicine (General) Lam, S.K. Poh, T.F. Ng, H.K. Hoe, S.Z. Gynura procumbens causes vasodilation by inhibiting angiotensin II and enhancing bradykinin actions |
| title | Gynura procumbens causes vasodilation by inhibiting
angiotensin II and enhancing bradykinin actions |
| title_full | Gynura procumbens causes vasodilation by inhibiting
angiotensin II and enhancing bradykinin actions |
| title_fullStr | Gynura procumbens causes vasodilation by inhibiting
angiotensin II and enhancing bradykinin actions |
| title_full_unstemmed | Gynura procumbens causes vasodilation by inhibiting
angiotensin II and enhancing bradykinin actions |
| title_short | Gynura procumbens causes vasodilation by inhibiting
angiotensin II and enhancing bradykinin actions |
| title_sort | gynura procumbens causes vasodilation by inhibiting angiotensin ii and enhancing bradykinin actions |
| topic | R Medicine (General) |
| url | http://eprints.um.edu.my/10502/1/Gynura_procumbens_Causes_Vasodilation_by_Inhibiting.pdf |
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