The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia
Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single...
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| Format: | Article |
| Language: | English |
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BioMed Central
2012
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| Online Access: | http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf |
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| author | Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. |
| author_facet | Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. |
| author_sort | Atroosh, W.M. |
| collection | UM |
| description | Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance |
| first_indexed | 2024-03-06T05:26:25Z |
| format | Article |
| id | um.eprints-10546 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:25Z |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | um.eprints-105462014-06-13T01:21:50Z http://eprints.um.edu.my/10546/ The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. Q Science (General) R Medicine (General) Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance BioMed Central 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf Atroosh, W.M. and Al-Mekhlafi, H.M. and Mahdy, M.A.K. and Surin, J. (2012) The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia. Malaria Journal. |
| spellingShingle | Q Science (General) R Medicine (General) Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title | The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_full | The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_fullStr | The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_full_unstemmed | The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_short | The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_sort | detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance pahang malaysia |
| topic | Q Science (General) R Medicine (General) |
| url | http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf |
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