Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia
Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in th...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2012
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10642/1/00004462_79448.pdf |
| _version_ | 1825719892724154368 |
|---|---|
| author | Baddam, Ramani Kumar, Narender Thong, Kwai Lin Ngoi, Soo Tein Teh, Cindy Shuan Ju Yap, Kien Pong Chai, Lay Ching Avasthi, Tiruvayipati Suma Ahmed, Niyaz |
| author_facet | Baddam, Ramani Kumar, Narender Thong, Kwai Lin Ngoi, Soo Tein Teh, Cindy Shuan Ju Yap, Kien Pong Chai, Lay Ching Avasthi, Tiruvayipati Suma Ahmed, Niyaz |
| author_sort | Baddam, Ramani |
| collection | UM |
| description | Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of Salmonella Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent Salmonella Typhi strain BL196/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere. |
| first_indexed | 2024-03-06T05:26:40Z |
| format | Article |
| id | um.eprints-10642 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:40Z |
| publishDate | 2012 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | um.eprints-106422019-12-03T04:39:33Z http://eprints.um.edu.my/10642/ Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia Baddam, Ramani Kumar, Narender Thong, Kwai Lin Ngoi, Soo Tein Teh, Cindy Shuan Ju Yap, Kien Pong Chai, Lay Ching Avasthi, Tiruvayipati Suma Ahmed, Niyaz Q Science (General) QH Natural history QR Microbiology Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of Salmonella Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent Salmonella Typhi strain BL196/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere. American Society for Microbiology 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10642/1/00004462_79448.pdf Baddam, Ramani and Kumar, Narender and Thong, Kwai Lin and Ngoi, Soo Tein and Teh, Cindy Shuan Ju and Yap, Kien Pong and Chai, Lay Ching and Avasthi, Tiruvayipati Suma and Ahmed, Niyaz (2012) Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia. Journal of Bacteriology, 194 (13). pp. 3565-3566. ISSN 0021-9193, DOI https://doi.org/10.1128/JB.00581-12 <https://doi.org/10.1128/JB.00581-12>. https://doi.org/10.1128/JB.00581-12 doi:10.1128/JB.00581-12 |
| spellingShingle | Q Science (General) QH Natural history QR Microbiology Baddam, Ramani Kumar, Narender Thong, Kwai Lin Ngoi, Soo Tein Teh, Cindy Shuan Ju Yap, Kien Pong Chai, Lay Ching Avasthi, Tiruvayipati Suma Ahmed, Niyaz Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title | Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title_full | Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title_fullStr | Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title_full_unstemmed | Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title_short | Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia |
| title_sort | genetic fine structure of a salmonella enterica serovar typhi strain associated with the 2005 outbreak of typhoid fever in kelantan malaysia |
| topic | Q Science (General) QH Natural history QR Microbiology |
| url | http://eprints.um.edu.my/10642/1/00004462_79448.pdf |
| work_keys_str_mv | AT baddamramani geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT kumarnarender geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT thongkwailin geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT ngoisootein geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT tehcindyshuanju geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT yapkienpong geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT chailayching geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT avasthitiruvayipatisuma geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia AT ahmedniyaz geneticfinestructureofasalmonellaentericaserovartyphistrainassociatedwiththe2005outbreakoftyphoidfeverinkelantanmalaysia |