Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension
Aim: The aim of the present study was to determine the existence or prevalence of thrombophilic markers such as Factor V Leiden, prothrombin G20210A, protein S, protein C, activated protein C and anti-thrombin in pre-eclampsia and pregnancy-induced hypertensive patients. Methods: Blood samples were...
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2008
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| author | Omar, S.Z. Qvist, R. Khaing, S.L. Muniandy, S. Bhalla, S. |
| author_facet | Omar, S.Z. Qvist, R. Khaing, S.L. Muniandy, S. Bhalla, S. |
| author_sort | Omar, S.Z. |
| collection | UM |
| description | Aim: The aim of the present study was to determine the existence or prevalence of thrombophilic markers such as Factor V Leiden, prothrombin G20210A, protein S, protein C, activated protein C and anti-thrombin in pre-eclampsia and pregnancy-induced hypertensive patients. Methods: Blood samples were collected from a total number of 124 women at the maternity unit, University of Malaya Medical Center. These included 49 patients with pre-eclampsia, 63 patients with pregnancy-induced hypertension and 12 normal pregnant women. DNA was extracted from the blood samples. Factor V Leiden (Taq I) and prothrombin G20210A (Hind III) genotyping was done on polymerase chain reaction-restriction fragment length polymorphism. Anti-thrombin activity and the concentrations of protein C, protein S and activated protein C were measured using the IL Coagulation System (Hemosil). Results: Of the 124 subjects, one pre-eclampsia patient was homozygous for Factor V Leiden mutation but prothrombin G20210A mutation was not present in any of the subjects. The subject with Factor V Leiden mutation also had a low activated protein C resistance and a low protein S concentration. Conclusions: Factor V Leiden mutation is present in the Asian population and may very well serve as one of the genetic factors responsible for pre-eclampsia and other adverse pregnancy outcomes. |
| first_indexed | 2024-03-06T05:27:11Z |
| format | Article |
| id | um.eprints-10863 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:27:11Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | um.eprints-108632014-07-14T00:35:59Z http://eprints.um.edu.my/10863/ Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension Omar, S.Z. Qvist, R. Khaing, S.L. Muniandy, S. Bhalla, S. R Medicine RG Gynecology and obstetrics Aim: The aim of the present study was to determine the existence or prevalence of thrombophilic markers such as Factor V Leiden, prothrombin G20210A, protein S, protein C, activated protein C and anti-thrombin in pre-eclampsia and pregnancy-induced hypertensive patients. Methods: Blood samples were collected from a total number of 124 women at the maternity unit, University of Malaya Medical Center. These included 49 patients with pre-eclampsia, 63 patients with pregnancy-induced hypertension and 12 normal pregnant women. DNA was extracted from the blood samples. Factor V Leiden (Taq I) and prothrombin G20210A (Hind III) genotyping was done on polymerase chain reaction-restriction fragment length polymorphism. Anti-thrombin activity and the concentrations of protein C, protein S and activated protein C were measured using the IL Coagulation System (Hemosil). Results: Of the 124 subjects, one pre-eclampsia patient was homozygous for Factor V Leiden mutation but prothrombin G20210A mutation was not present in any of the subjects. The subject with Factor V Leiden mutation also had a low activated protein C resistance and a low protein S concentration. Conclusions: Factor V Leiden mutation is present in the Asian population and may very well serve as one of the genetic factors responsible for pre-eclampsia and other adverse pregnancy outcomes. 2008 Article PeerReviewed Omar, S.Z. and Qvist, R. and Khaing, S.L. and Muniandy, S. and Bhalla, S. (2008) Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension. Journal of Obstetrics and Gynaecology Research, 34 (2). pp. 174-178. ISSN 1341-8076, DOI https://doi.org/10.1111/j.1447-0756.2008.00755.x <https://doi.org/10.1111/j.1447-0756.2008.00755.x>. http://onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2008.00755.x/full 10.1111/j.1447-0756.2008.00755.x |
| spellingShingle | R Medicine RG Gynecology and obstetrics Omar, S.Z. Qvist, R. Khaing, S.L. Muniandy, S. Bhalla, S. Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title_full | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title_fullStr | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title_full_unstemmed | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title_short | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension |
| title_sort | thrombophilic mutations in pre eclampsia and pregnancy induced hypertension |
| topic | R Medicine RG Gynecology and obstetrics |
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